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HomeProduct name listMepitiostane

Mepitiostane

Mepitiostane Structural

What is Mepitiostane?

Originator

Thioderon,Shionogi,Japan,1979

The Uses of Mepitiostane

An orally active anabolic and androgenic steroid. It is a steroidal anti-estrogen with anti-mammary tumor activity.

Definition

ChEBI: Mepitiostane is an organic molecular entity.

Manufacturing Process

A mixture of 1.759 g of 2α,3α-epithio-5α-androstan-17β-ol, 2.3 ml of 1- methoxycyclopentene, 20 mg of pyridine salt of p-toluenesulfonic acid and 20 ml of t-butanol is stirred for 4 hours at room temperature. The reaction mixture is poured into an aqueous solution of sodium carbonate and the whole extracted with dichloromethane. The extract is dried over anhydrous sodium sulfate and evaporated to remove solvent. Purification of the residue by chromatography over alumina gives 1.487 g of 17β-(1-methoxycyclopentyl) oxy-2α,3α-epithio-5α-androstane. Yield 68.2%. MP 98°C to 101°C.

Therapeutic Function

Antiestrogen

Properties of Mepitiostane

Melting point: 98-101°
Boiling point: 496.21°C (rough estimate)
alpha  D20 +22.5 ±0.5° (c = 1 in chloroform)
Density  0.9998 (rough estimate)
refractive index  1.5200 (estimate)
solubility  Chloroform (Slightly), Ethyl Acetate (Slightly)
form  Solid
color  White to Off-White
Stability: Acid Sensitive

Safety information for Mepitiostane

Computed Descriptors for Mepitiostane

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