Mepitiostane
- CAS NO.:21362-69-6
- Empirical Formula: C25H40O2S
- Molecular Weight: 404.65
- MDL number: MFCD00866517
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:44:01
What is Mepitiostane?
Originator
Thioderon,Shionogi,Japan,1979
The Uses of Mepitiostane
An orally active anabolic and androgenic steroid. It is a steroidal anti-estrogen with anti-mammary tumor activity.
Definition
ChEBI: Mepitiostane is an organic molecular entity.
Manufacturing Process
A mixture of 1.759 g of 2α,3α-epithio-5α-androstan-17β-ol, 2.3 ml of 1- methoxycyclopentene, 20 mg of pyridine salt of p-toluenesulfonic acid and 20 ml of t-butanol is stirred for 4 hours at room temperature. The reaction mixture is poured into an aqueous solution of sodium carbonate and the whole extracted with dichloromethane. The extract is dried over anhydrous sodium sulfate and evaporated to remove solvent. Purification of the residue by chromatography over alumina gives 1.487 g of 17β-(1-methoxycyclopentyl) oxy-2α,3α-epithio-5α-androstane. Yield 68.2%. MP 98°C to 101°C.
Therapeutic Function
Antiestrogen
Properties of Mepitiostane
Melting point: | 98-101° |
Boiling point: | 496.21°C (rough estimate) |
alpha | D20 +22.5 ±0.5° (c = 1 in chloroform) |
Density | 0.9998 (rough estimate) |
refractive index | 1.5200 (estimate) |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
form | Solid |
color | White to Off-White |
Stability: | Acid Sensitive |
Safety information for Mepitiostane
Computed Descriptors for Mepitiostane
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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