Mepitiostane
- CAS NO.:21362-69-6
- Empirical Formula: C25H40O2S
- Molecular Weight: 404.65
- MDL number: MFCD00866517
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-15 10:44:01
What is Mepitiostane?
Originator
Thioderon,Shionogi,Japan,1979
The Uses of Mepitiostane
An orally active anabolic and androgenic steroid. It is a steroidal anti-estrogen with anti-mammary tumor activity.
Definition
ChEBI: Mepitiostane is an organic molecular entity.
Manufacturing Process
A mixture of 1.759 g of 2α,3α-epithio-5α-androstan-17β-ol, 2.3 ml of 1- methoxycyclopentene, 20 mg of pyridine salt of p-toluenesulfonic acid and 20 ml of t-butanol is stirred for 4 hours at room temperature. The reaction mixture is poured into an aqueous solution of sodium carbonate and the whole extracted with dichloromethane. The extract is dried over anhydrous sodium sulfate and evaporated to remove solvent. Purification of the residue by chromatography over alumina gives 1.487 g of 17β-(1-methoxycyclopentyl) oxy-2α,3α-epithio-5α-androstane. Yield 68.2%. MP 98°C to 101°C.
Therapeutic Function
Antiestrogen
Properties of Mepitiostane
Melting point: | 98-101° |
Boiling point: | 496.21°C (rough estimate) |
alpha | D20 +22.5 ±0.5° (c = 1 in chloroform) |
Density | 0.9998 (rough estimate) |
refractive index | 1.5200 (estimate) |
solubility | Chloroform (Slightly), Ethyl Acetate (Slightly) |
form | Solid |
color | White to Off-White |
Stability: | Acid Sensitive |
Safety information for Mepitiostane
Computed Descriptors for Mepitiostane
New Products
Tubulysin D Tubulysin I Tubulysin M 2,2-diethoxyethanethioamide Tubulysin H 2H-Pyran, 4-ethynyltetrahydro- 3-N-BOC-(S)-AMINO BUTYRONITRILE 2,2-Difluoropropylamine hydrochloride 4-(Benzyloxy)-3-bromophenylacetic Acid CYCLOBUTYLAMINE HYDROCHLORIDE 4,4-DIFLUOROCYCLOHEXANAMINE 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Calcium Sodium Phosphosilicate IH Imeglimin Hydrochloride IH (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Fuel shell 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Lubiprostone Magnesium Trisilicate Latanoprostene Bunod Flame Retardant Zinc Borate methyl 3-fluoro-4- thiomorpholino phenylcarbamate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
(R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonateView Details
2416850-45-6 -
methyl 3-fluoro-4- thiomorpholino phenylcarbamateView Details
2760359-22-4 -
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
Hydrogen Gas 98%View Details
-
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8