mefruside

CAS NO.：7195-27-9
Empirical Formula: C13H19ClN2O5S2
Molecular Weight: 382.88
MDL number: MFCD00867319
EINECS: 2305624
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is mefruside?

Originator

Baycaron,Bayer,W. Germany,1967

The Uses of mefruside

Mefruside is a diuretic used for the treatment of edema and hypertension.

Definition

ChEBI: Mefruside is an organic molecular entity.

Manufacturing Process

By hydrogenation of α-methyl-α-cyanotetrahydrofuran with Raney nickel as catalyst, α-methyl-α-tetrahydrofurfuryl amine is obtained (BP 48°C/12 mm Hg) which is alkylated by dimethyl sulfate to give α-methyl-αtetrahydrofurfurylmethylamine (BP 70°C/40 mm Hg). The amine is then reacted with 4-chloro-3-sulfamyl benzene sulfochloride in the presence of an acid acceptor. The mixture is stirred overnight, the solvent (acetone or pyridine) is driven off under vacuum and the residue is recrystallized from alcohol.

Therapeutic Function

Diuretic

Properties of mefruside

Melting point:	149.5°C
Boiling point:	565.2±60.0 °C(Predicted)
Density	1.3150 (rough estimate)
refractive index	1.6100 (estimate)
storage temp.	Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka	9.26±0.60(Predicted)
form	Solid
color	White to Pale Beige
Stability:	Hygroscopic