macbecin I
- CAS NO.：73341-72-7
- Empirical Formula: C30H42N2O8
- Molecular Weight: 558.67
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:30:59
What is macbecin I?
The Uses of macbecin I
Macbecin I is an ansamycin antibiotic inhibitor of Hsp90 activity.
What are the applications of Application
Macbecin I is an ansamycin antibiotic inhibitor of Hsp90 activity
Biological Activity
Ansamycin antibiotic compound that inhibits Hsp90 activity (IC 50 = 2 μ M) by binding to the ATP-binding site. Exhibits antitumor and cytocidal activities (IC 50 ~ 0.4 μ M) by causing degradation of key oncogenic client proteins such as ErbB2 and cRaf1. Displays higher affinity and potency than geldanamycin (9,13-Dihydroxy-8,14,19-trimethoxy-4,10,12,16-tetramethyl-2-azabicyclo[16.3.1]docosa-4,6,10,18,21-pentaene-3,20,22-trione, 9-carbamate ).
Properties of macbecin I
| Melting point: | 205-206 °C(Solv: ethanol (64-17-5); water (7732-18-5)) |
| Boiling point: | 736.2±60.0 °C(Predicted) |
| Density | 1.17±0.1 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | Soluble in DMSO > 10 mM |
| form | Powder |
| pka | 8.62±0.70(Predicted) |
Safety information for macbecin I
Computed Descriptors for macbecin I
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