LY411575
Synonym(s):LSN-411575;LY 411575;N2-[(2S)-2-(3,5-Difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide
- CAS NO.:209984-57-6
- Empirical Formula: C26H23F2N3O4
- Molecular Weight: 479.48
- MDL number: MFCD09832551
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:16
What is LY411575?
Description
γ-
The Uses of LY411575
LY-411575 has been used as a potent γ-secretase inhibitor and Notch inhibitor.
What are the applications of Application
LY411575 is a potent γ-secretase inhibitor
Definition
ChEBI: A dibenzoazepine that is 5,7-dihydro-6H-dibenzo[b,d]azepin-6-one which is substituted at the 7 pro-S position by the C-terminal carboxamide nitrogen of N /element>2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]-L-alaninamide. It is a potent, cell permeable and selective gamma-secretase inhibitor. It has been tested as a possible treatment for Alzheimer's disease and shows promise for its potential to counteract severe hearing loss.
Biochem/physiol Actions
LY-411575 is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. Studies (Cancer Cell) have shown that treatment with LSN-411575 arrests KrasG12V-driven NSCLCs in association with inhibition of HES1 expression and ERK phosphorylation.
Properties of LY411575
Boiling point: | 836.0±65.0 °C(Predicted) |
Density | 1.40 |
storage temp. | -20°C |
solubility | DMSO: soluble5mg/mL, clear |
pka | 11.79±0.20(Predicted) |
form | powder |
color | white to beige |
Safety information for LY411575
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention. |
Computed Descriptors for LY411575
InChIKey | ULSSJYNJIZWPSB-CVRXJBIPSA-N |
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde 6-chloropyridine-3,4-diamine S(-)3-Amino tetrahydrofuran Rimegepant Impurity 3 Ivermectin EP Impurity B Fosfomycin EP impurity D 2,2-diethoxyethanethioamide Tubulysin M Tubulysin I Tubulysin G Tubulysin E 2-chloro-5-nitropyridin-4-amine 6-chloro-4-methylnicotinonitrile 6-chloropicolinonitrile 5-bromo-2-methoxy-4-methyl-3-nitropyridine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (S)-Methyl 2-((tert-butoxycarbonyl)amino)-3-((S)-2-oxopyrrolidin-3-yl)propanoate 2-(2,4-Dibutoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolaneRelated products of tetrahydrofuran
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