FLI-06
Synonym(s):1,4,5,6,7,8-Hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylic acid cyclohexyl ester
- CAS NO.：313967-18-9
- Empirical Formula: C25H30N2O5
- Molecular Weight: 438.52
- MDL number: MFCD00330996
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-18 11:31:20
What is FLI-06?
Description
FLI-06 (313967-18-9) was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It was found to disrupt the Golgi apparatus in a manner distinct from that of brefeldin A. It inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER. Thus FLI-06 is the first small molecule acting at such an early stage in secretory traffic.1
The Uses of FLI-06
FLI-06 is a novel inhibitor of Notch signalling and the early secretory pathway.
References
1) Kramer?et al., (2013),?Small molecules intercept Notch signaling and the early secretory pathway; Nat. Chem. Biol.?9 731
Properties of FLI-06
| Melting point: | 199-202oC |
| Boiling point: | 597.5±50.0 °C(Predicted) |
| Density | 1.25±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble5mg/mL, clear (warmed) |
| pka | 0.78±0.70(Predicted) |
| form | powder |
| color | white to beige |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week. |
Safety information for FLI-06
Computed Descriptors for FLI-06
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde 4-(4-Bromo-3-formylphenoxy)benzonitrile Ivermectin EP Impurity B Fosfomycin EP impurity D Rimegepant Impurity 3 Tubulysin A Tubulysin B Tubulysin G Tubulysin E Tubulysin M Tubulysin H 2-chloro-5-nitropyridin-4-amine 7-fluoro-1-methyl-1H-Indole-2,3-dione 2-bromo-5-methyl-4-nitropyridine 1-oxide 2-chloro-6-methylpyridin-4-amine 3-bromo-6-chloro-2-methyl-5-nitropyridine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Calcium Sodium Phosphosilicate IH 3-Morpholino-5,6-dihydropyridin-2(1H)-oneRelated products of tetrahydrofuran
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