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HomeProduct name listLY 223982

LY 223982

LY 223982 Structural

What is LY 223982?

Description

Leukotriene B4 (LTB4) is a dihydroxy fatty acid derived from the 5-lipoxygenase pathway of arachidonic acid metabolism and is an important mediator of the inflammatory process. The benzophenone dicarboxylic acid derivative LY223982 is a potent BLT1 receptor antagonist. It inhibits the specific binding of radiolabeled-LTB4 to isolated human neutrophils with an IC50 value of 13.2 nM. LY223982 inhibits the leukotriene B4 (LTB4)-induced aggregation of guinea pig and human neutrophils with IC50 values of 74 and 100 nM, respectively. However, concentrations of LY223982 up to 10 μM do not inhibit binding of LTB4 to human BLT1 or BLT2 expressed in CHO cells.

The Uses of LY 223982

LY223982 is a potent P2Y7 (BLT1) receptor antagonist.

What are the applications of Application

LY223982 is a potent P2Y7 (BLT1) receptor antagonist

Properties of LY 223982

Melting point: 151-152 °C
Boiling point: 753.8±60.0 °C(Predicted)
Density  1.235±0.06 g/cm3(Predicted)
storage temp.  -20°C Freezer
solubility  Chloroform (Slightly, Heated, Sonicated), DMSO (Very Slightly)
pka 3.81±0.10(Predicted)
form  A crystalline solid
color  White to off-white

Safety information for LY 223982

Computed Descriptors for LY 223982

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