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HomeProduct name listLosartan Impurity 12

Losartan Impurity 12

  • CAS NO.:727718-93-6
  • Empirical Formula: C22H22ClN9
  • Molecular Weight: 447.93
  • Update Date: 2023-05-18 11:31:19
Losartan Impurity 12 Structural

What is Losartan Impurity 12?

Description

Losartan is a medication used to treat high blood pressure. It is also used for diabetic kidney disease, heart failure, and left ventricular enlargement.Losartan was patented in 1986, and approved for medical use in the United States in 1995. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication.
Losartan was the first nonpeptide imidazole to beintroduced as an orally active angiotensin II antagonist withhigh specificity for AT1. When administered to patients, itundergoes extensive first-pass metabolism, with the 5-methanol being oxidized to a carboxylic acid. This metabolismis mediated by CYP 2C9 and 3A4 isozymes. The 5-methanol metabolite is approximately 15 times more potentthan the parent hydroxyl compound. Because the parent hydroxylcompound has affinity for the AT1 receptor, strictlyspeaking, it is not a prodrug.

The Uses of Losartan Impurity 12

Losartan Azide is an impurity of Losartan (L470470). Losartan is a nonpeptide angiotensin II AT1-receptor antagonist. Antihypertensive.

Properties of Losartan Impurity 12

Melting point: >139°C (dec.)
storage temp.  -20°C Freezer
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
color  White to Off-White

Safety information for Losartan Impurity 12

Computed Descriptors for Losartan Impurity 12

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