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HomeProduct name listLOGANIC ACID

LOGANIC ACID

Synonym(s):Loganate

  • CAS NO.:22255-40-9
  • Empirical Formula: C16H24O10
  • Molecular Weight: 376.36
  • MDL number: MFCD00017417
  • EINECS: 244-875-9
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
LOGANIC ACID Structural

What is LOGANIC ACID?

Description

Loganic acid is an iridoid glycoside that has been found in C. mas and has diverse biological activities, including antidiabetic, antiadipogenic, anti-atherosclerotic, and anti-inflammatory properties. Loganic acid (1 μM) stimulates glucagon-like peptide-1 (GLP-1) secretion by NCI H716 human enteroendocrine colorectal cancer cells. It inhibits dexamethasone-, 3-isobutyl-1-methylxanthine-, and insulin-induced differentiation of mouse 3T3-L1 fibroblasts into adipocytes when used at a concentration of 10 μg/ml. Loganic acid (20 mg/kg per day) decreases the plasma atherogenic index, a ratio of triglyceride to HDL cholesterol, and the cardiac risk ratio, a ratio of total cholesterol to HDL cholesterol, in a rabbit model of atherosclerosis induced by a cholesterol-rich diet. It also decreases IL-6, TNF-α, and oxidized LDL (oxLDL) plasma levels in the same model.

The Uses of LOGANIC ACID

Loganic Acid is found to be present in both the fermented fruits and brines. Exhibits antioxidant activity.

Definition

ChEBI: A cyclopentapyran that is 1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid substituted at positions 1, 6 and 7 by beta-D-glucosyloxy, hydroxy and methyl groups respectively

Properties of LOGANIC ACID

Boiling point: 646.3±55.0 °C(Predicted)
Density  1.60±0.1 g/cm3(Predicted)
storage temp.  -20°C
solubility  Soluble in methan
form  powder
pka 4.55±0.70(Predicted)
color  White-beige

Safety information for LOGANIC ACID

Computed Descriptors for LOGANIC ACID

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