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HomeProduct name listLIDOFLAZINE, 98.5%

LIDOFLAZINE, 98.5%

  • CAS NO.:3416-26-0
  • Empirical Formula: C30H35F2N3O
  • Molecular Weight: 491.62
  • MDL number: MFCD00057353
  • EINECS: 222-312-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-28 23:16:16
LIDOFLAZINE, 98.5% Structural

What is LIDOFLAZINE, 98.5%?

Chemical properties

WHITE TO ALMOST WHITE POWDER

Originator

Clinium,Janssen,W. Germany,1969

The Uses of LIDOFLAZINE, 98.5%

Coronary vasodilatator;Ca++ channel activator

The Uses of LIDOFLAZINE, 98.5%

Lidoflazine is a L-type Ca2+ channel antagonist.Also, it is derived from 1,1''-(4-Chlorobutylidene)bis(4-fluorobenzene) (C364775), which is a derivative of Zerumbone with potential anti-tumor effects towards HeLa cancer cells.

What are the applications of Application

Lidoflazine is an antianginal calcium channel protein inhibitor

Definition

ChEBI: 2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide is a diarylmethane.

Manufacturing Process

A mixture of 6.6 parts 1-[4,4-di-(4-fluoro-phenyl)butyl]-piperazine, 4.33 parts N-(2-chloro-acetyl)-2,6-dimethyl-aniline, 3.2 parts sodium carbonate, a few crystals of potassium iodide in 200 parts 4-methyl-2-pentanone is stirred and refluxed for 70 hours. After cooling there are added 70 parts water. The organic layer is separated, dried over potassium carbonate, filtered and evaporated. The oily residue is dissolved in 80 parts diisopropylether and the solution is filtered hot. After cooling the filtrate at 0°C. the formed solid is filtered off and recystallired from 80 parts ether, yielding 1-[4,4-di-(4-fluorophenyl)butyl]-4-[(2,6-dimethylanilino-carbonyl)-methyl]-piperazine; MP 159°C to 161°C.

brand name

Angex (Janssen); Clinium (Ortho-McNeil).

Therapeutic Function

Coronary vasodilator

Metabolism

Not Available

Properties of LIDOFLAZINE, 98.5%

Melting point: 159-161°
Boiling point: 632.6±55.0 °C(Predicted)
Density  1.1322 (estimate)
storage temp.  2-8°C
solubility  DMSO: ≥10mg/mL
form  powder
pka 14.62±0.70(Predicted)
color  white
CAS DataBase Reference 3416-26-0

Safety information for LIDOFLAZINE, 98.5%

Computed Descriptors for LIDOFLAZINE, 98.5%

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