LIDOFLAZINE, 98.5%
- CAS NO.:3416-26-0
- Empirical Formula: C30H35F2N3O
- Molecular Weight: 491.62
- MDL number: MFCD00057353
- EINECS: 222-312-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is LIDOFLAZINE, 98.5%?
Chemical properties
WHITE TO ALMOST WHITE POWDER
Originator
Clinium,Janssen,W. Germany,1969
The Uses of LIDOFLAZINE, 98.5%
Coronary vasodilatator;Ca++ channel activator
The Uses of LIDOFLAZINE, 98.5%
Lidoflazine is a L-type Ca2+ channel antagonist.Also, it is derived from 1,1''-(4-Chlorobutylidene)bis(4-fluorobenzene) (C364775), which is a derivative of Zerumbone with potential anti-tumor effects towards HeLa cancer cells.
What are the applications of Application
Lidoflazine is an antianginal calcium channel protein inhibitor
Definition
ChEBI: 2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide is a diarylmethane.
Manufacturing Process
A mixture of 6.6 parts 1-[4,4-di-(4-fluoro-phenyl)butyl]-piperazine, 4.33 parts N-(2-chloro-acetyl)-2,6-dimethyl-aniline, 3.2 parts sodium carbonate, a few crystals of potassium iodide in 200 parts 4-methyl-2-pentanone is stirred and refluxed for 70 hours. After cooling there are added 70 parts water. The organic layer is separated, dried over potassium carbonate, filtered and evaporated. The oily residue is dissolved in 80 parts diisopropylether and the solution is filtered hot. After cooling the filtrate at 0°C. the formed solid is filtered off and recystallired from 80 parts ether, yielding 1-[4,4-di-(4-fluorophenyl)butyl]-4-[(2,6-dimethylanilino-carbonyl)-methyl]-piperazine; MP 159°C to 161°C.
brand name
Angex (Janssen); Clinium (Ortho-McNeil).
Therapeutic Function
Coronary vasodilator
Metabolism
Not Available
Properties of LIDOFLAZINE, 98.5%
Melting point: | 159-161° |
Boiling point: | 632.6±55.0 °C(Predicted) |
Density | 1.1322 (estimate) |
storage temp. | 2-8°C |
solubility | DMSO: ≥10mg/mL |
form | powder |
pka | 14.62±0.70(Predicted) |
color | white |
CAS DataBase Reference | 3416-26-0 |
Safety information for LIDOFLAZINE, 98.5%
Computed Descriptors for LIDOFLAZINE, 98.5%
New Products
4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Mefenamic Acid IP/BP/EP/USP Diclofenac Sodium IP/BP/EP/USP Ornidazole IP Diclofenac Potassium SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
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