LIDOFLAZINE, 98.5%
- CAS NO.:3416-26-0
- Empirical Formula: C30H35F2N3O
- Molecular Weight: 491.62
- MDL number: MFCD00057353
- EINECS: 222-312-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-28 23:16:16
What is LIDOFLAZINE, 98.5%?
Chemical properties
WHITE TO ALMOST WHITE POWDER
Originator
Clinium,Janssen,W. Germany,1969
The Uses of LIDOFLAZINE, 98.5%
Coronary vasodilatator;Ca++ channel activator
The Uses of LIDOFLAZINE, 98.5%
Lidoflazine is a L-type Ca2+ channel antagonist.Also, it is derived from 1,1''-(4-Chlorobutylidene)bis(4-fluorobenzene) (C364775), which is a derivative of Zerumbone with potential anti-tumor effects towards HeLa cancer cells.
What are the applications of Application
Lidoflazine is an antianginal calcium channel protein inhibitor
Definition
ChEBI: 2-[4-[4,4-bis(4-fluorophenyl)butyl]-1-piperazinyl]-N-(2,6-dimethylphenyl)acetamide is a diarylmethane.
Manufacturing Process
A mixture of 6.6 parts 1-[4,4-di-(4-fluoro-phenyl)butyl]-piperazine, 4.33 parts N-(2-chloro-acetyl)-2,6-dimethyl-aniline, 3.2 parts sodium carbonate, a few crystals of potassium iodide in 200 parts 4-methyl-2-pentanone is stirred and refluxed for 70 hours. After cooling there are added 70 parts water. The organic layer is separated, dried over potassium carbonate, filtered and evaporated. The oily residue is dissolved in 80 parts diisopropylether and the solution is filtered hot. After cooling the filtrate at 0°C. the formed solid is filtered off and recystallired from 80 parts ether, yielding 1-[4,4-di-(4-fluorophenyl)butyl]-4-[(2,6-dimethylanilino-carbonyl)-methyl]-piperazine; MP 159°C to 161°C.
brand name
Angex (Janssen); Clinium (Ortho-McNeil).
Therapeutic Function
Coronary vasodilator
Metabolism
Not Available
Properties of LIDOFLAZINE, 98.5%
Melting point: | 159-161° |
Boiling point: | 632.6±55.0 °C(Predicted) |
Density | 1.1322 (estimate) |
storage temp. | 2-8°C |
solubility | DMSO: ≥10mg/mL |
form | powder |
pka | 14.62±0.70(Predicted) |
color | white |
CAS DataBase Reference | 3416-26-0 |
Safety information for LIDOFLAZINE, 98.5%
Computed Descriptors for LIDOFLAZINE, 98.5%
New Products
(R)-(-)-2-Amino-1-propanol Tetrahydro-4H-pyran-4-one Bromine 99.5% AR (4 x 500ml) Linseed Oil Extrapure Hydrogen Sulphide Solution Oxalic Acid 0.05 mol/L (0.01N) Solution EDTA 0.1 mol/L (0.2N) for 1000 ml Ferroin 0.025M Solution AR 1,2,3,4-Tetrahydrocarbazol-4-one 4-Hydroxy Carbazole Amino Salicylic Acid. U.S.P. 2 – Methoxy – 5- Sulfamoyl Benzoic acid Acetone Isobutryl oxime ester Sodium Amino Salicylate Dihydrate (PAS Sodium) IP/BP/USP/EP Aloe vera extract 200x Withania somnifera (Ashwagandha Extract) Citrus bioflavonoids Extract Spirulina (Arthrospira platensis) Powder Trikatu Extract Thymol Oil Ethyl 3-(Pyridin-2-Ylamino)Propanoate Bilastine -IP/BP/ Cypermethric Acid Chloride 5-NitrosalicylaldehydeRelated products of tetrahydrofuran
You may like
-
Lidoflazine CAS 3416-26-0View Details
3416-26-0 -
7726-95-6 Bromine 99.5% AR (4 x 500ml) 99%View Details
7726-95-6 -
Formamide 99%View Details
75-12-7 -
85-81-4 6-Methoxy-8-Nitroquinoline 99%View Details
85-81-4 -
3-Bromo-4,5-Dihydro-1H-Benzo[B]Azepin-2(3H)-One 99%View Details
86499-96-9 -
(−)-Dip-Chloride 85116-37-6 99%View Details
85116-37-6 -
29943-42-8 Tetrahydro-4H-pyran-4-one 98+View Details
29943-42-8 -
35320-23-1 98+View Details
35320-23-1