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HomeProduct name listlevorphanol

levorphanol

levorphanol  Structural

What is levorphanol ?

Absorption

Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.

Toxicity

LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.

The Uses of levorphanol

Levorphanol is an intermediate in the synthesis of Levorphanol L-Tartrate(L376500). Levorphanol Tartrate is an orally active synthetic morphine analog. Analgesic (narcotic). Controlled substance.

The Uses of levorphanol

Analgesic(narcotic).

Indications

For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate.

Background

A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.

Definition

ChEBI: Levorphanol is a morphinane alkaloid.

brand name

Levo-Dromoran (Valeant).

Pharmacokinetics

Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.

Metabolism

Levorphanol is extensively metabolized in the liver and is eliminated as the glucuronide metabolite.

Properties of levorphanol

Melting point: 198-199°
Boiling point: 400.62°C (rough estimate)
alpha  D20 -56° (c = 3 in absolute alcohol)
Density  0.9711 (rough estimate)
refractive index  1.5200 (estimate)
pka 10.07±0.20(Predicted)

Safety information for levorphanol

Computed Descriptors for levorphanol

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