levorphanol
- CAS NO.:77-07-6
- Empirical Formula: C17H23NO
- Molecular Weight: 257.37
- EINECS: 201-002-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-09 09:30:21
What is levorphanol ?
Absorption
Levorphanol is well absorbed after PO administration with peak plasma concentrations occurring approximately 1 hour after dosing.
Toxicity
LD50=150 mg/kg (orally in rats). Signs of overdose include nausea, emesis, dizziness, respiratory depression, hypotension, urinary retention, cardiac arrhythmias, allergic reactions, skin rash, and uticaria.
The Uses of levorphanol
Levorphanol is an intermediate in the synthesis of Levorphanol L-Tartrate(L376500). Levorphanol Tartrate is an orally active synthetic morphine analog. Analgesic (narcotic). Controlled substance.
The Uses of levorphanol
Analgesic(narcotic).
Indications
For the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate.
Background
A narcotic analgesic that may be habit-forming. It is nearly as effective orally as by injection.
Definition
ChEBI: Levorphanol is a morphinane alkaloid.
brand name
Levo-Dromoran (Valeant).
Pharmacokinetics
Levorphanol is a potent synthetic opioid analgesic indicated for the management of moderate to severe pain or as a preoperative medication where an opioid analgesic is appropriate. Levorphanol is similar to morphine in its actions, however it is up to 8 times more potent than morphine. Levorphanol produces a degree of respiratory depression similar to that produced by morphine at equianalgesic doses, and like many mu-opioid drugs, levorphanol produces euphoria or has a positive effect on mood in many individuals.
Metabolism
Levorphanol is extensively metabolized in the liver and is eliminated as the glucuronide metabolite.
Properties of levorphanol
Melting point: | 198-199° |
Boiling point: | 400.62°C (rough estimate) |
alpha | D20 -56° (c = 3 in absolute alcohol) |
Density | 0.9711 (rough estimate) |
refractive index | 1.5200 (estimate) |
pka | 10.07±0.20(Predicted) |
Safety information for levorphanol
Computed Descriptors for levorphanol
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