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HomeProduct name listLEE011 (succinate)

LEE011 (succinate)

  • CAS NO.:1374639-75-4
  • Empirical Formula: C27H36N8O5
  • Molecular Weight: 552.64
  • Update Date: 2024-11-11 20:33:26
LEE011 (succinate) Structural

What is LEE011 (succinate)?

The Uses of LEE011 (succinate)

LEE011 is an orally bioavailable and highly specific CDK4/6 (cyclin-dependent kinase 4/6) inhibitor. LEE011 in combination with LGX818 (a V600E BRAF specific inhibitor) or BYL719 (a PIK3CA specific inhibitor) leads to robust anti-tumor activity in melanoma and breast cancer tumor models.

What are the applications of Application

LEE011 Succinate is an inhibitor of Cdk4 and Cdk6

Properties of LEE011 (succinate)

Melting point: >160oC (dec.)
storage temp.  Refrigerator
solubility  DMSO (Slightly), Methanol (Slightly)
form  Solid
color  Pale Beige

Safety information for LEE011 (succinate)

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
ghs
Health Hazard
GHS08
ghs
Environment
GHS09
GHS Hazard Statements H301:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H372:Specific target organ toxicity, repeated exposure
H400:Hazardous to the aquatic environment, acute hazard
Precautionary Statement Codes P273:Avoid release to the environment.
P314:Get medical advice/attention if you feel unwell.
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for LEE011 (succinate)

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