L-xylulose
- CAS NO.:527-50-4
- Empirical Formula: C5H10O5
- Molecular Weight: 150.13
- MDL number: MFCD00064286
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-10-23 13:36:13
What is L-xylulose?
Chemical properties
L-xylulose is a clear liquid. It is a ketopentose, meaning that it has five carbon atoms and a ketogroup at carbon C-2. It has a molecular formula of C5H10O5 and a molar mass of 150.13 g/mol. Xylulose is almost colorless and it forms syrup. The formation of crystals has not been reported (Budavari, 1996). Both D- and L - enantiomers of xylulose are found as intermediates in metabolic pathways of prokaryotes as well as eukaryotes. Both forms are rare in nature (Doten and Mortlock, 1985b).
The Uses of L-xylulose
L-Xylulose is used in studies relating to potential inhibitors of glycosidases and has been proven to inhibit oligosaccharide processing to a degree.
What are the applications of Application
L-Xylulose is a monosaccharide
Definition
ChEBI: L-xylulose is a xylulose. It has a role as a human metabolite, an Escherichia coli metabolite and a mouse metabolite. It is an enantiomer of a D-xylulose.
What are the applications of Application
L-Xylulose has been shown to be a specific inhibitor of certain α-glucosidases,while having virtually no effect on other glycosidases such as β-glucosidase or α- and β-mannosidases. Furthermore,it is a specific inhibitor of the N-linked glycoproteinprocessing enzyme,glucosidase I, but does not inhibit glucosidase I or otherglycoprotein processing mannosidases. Thus it could prove to be a useful inhibitor forstudying glycoprotein processing, especially as it has been proven to be non-toxic andto also be effective in cell cultures (Muniruzzaman et al., 1996). L-Xylulose has been shown to have a strong inhibitory effect on the a-glucosidases,sucrase and maltase, present in the small intestine. Thus, an L-xylulose containing drug preparation for reducing blood sugar levels in humans and animals has been patented (Heinz et al.,1998).
Preparation
In 1933 a synthetic procedure for producing small amounts of D- and L -xylulose was introduced. In this method D- or L-xylose is epimerized to the corresponding diastereomer. The isomerization of xylose in pyridine leads to the production of xylulose (Touster, 1962). This enzyme catalyzes the production of L-xylulose from xylitol using either PQQ (pyrroloquinoline quinone) or FAD (flavin adenine dinucleotide) as prosthetic group, and L-xylulose is accumulated in the medium (Adachi et al., 1999; Adachi et al., 2001).
Properties of L-xylulose
Melting point: | Not Applicable |
Boiling point: | 469.1±45.0 °C(Predicted) |
Density | 1.516±0.06 g/cm3(Predicted) |
Flash point: | >230 °F |
storage temp. | 2-8°C |
solubility | Methanol (Slightly), Water (Soluble) |
pka | 11.90±0.20(Predicted) |
form | syrup |
color | light yellow |
Safety information for L-xylulose
Computed Descriptors for L-xylulose
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