L-SELENOCYSTINE
Synonym(s):(R,R)-3,3′-Diseleno-bis(2-aminopropionic acid);L -Selenocystine
- CAS NO.：29621-88-3
- Empirical Formula: C6H12N2O4Se2
- Molecular Weight: 334.09
- MDL number: MFCD00800971
- EINECS: 608-382-6
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-05-27 18:13:48
What is L-SELENOCYSTINE?
Description
L-Selenocystine is a diselenide-bridged amino acid that may be confused with selenocysteine (Sec), which is a rare amino acid featuring a single selenium atom. L-Selenocystine is a redox-active selenium compound that has both anti- and pro-oxidant actions. This compound can be reduced by low molecular thiols and disulfide reductases to Sec. It is reduced to Sec by mammalian thioredoxin reductase (apparent Km = 6.0 μM), and this property can be used to assay thioredoxin reductase activity. L-Selenocystine induces an unfolded protein response, ER stress, and large cytoplasmic vacuolization in HeLa cells and has cytostatic effects in a range of cancer cell types.
Chemical properties
yellow fine powder
The Uses of L-SELENOCYSTINE
Seleno-L-cystine can be used for the synthesis of:
- Biologically active selenol compounds.
- Non-natural selenylated diamino acids.
Properties of L-SELENOCYSTINE
| Melting point: | 224.5-229.5 °C (lit.) |
| Boiling point: | 538.3±60.0 °C(Predicted) |
| storage temp. | 2-8°C |
| solubility | Aqueous Acid (Slightly), Aqueous Base (Slightly) |
| form | Powder |
| pka | 1.69±0.10(Predicted) |
| color | Yellow |
| optical activity | [α]20/D 28°, c = 1 in NaOH |
| BRN | 1969559 |
| Stability: | Hygroscopic |
Safety information for L-SELENOCYSTINE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06  Health Hazard GHS08  Environment GHS09 |
| GHS Hazard Statements |
H373:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard |
| Precautionary Statement Codes |
P273:Avoid release to the environment. P314:Get medical advice/attention if you feel unwell. |
Computed Descriptors for L-SELENOCYSTINE
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