L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-
- CAS NO.:1948273-02-6
- Empirical Formula: C23H32N4O3S
- Molecular Weight: 444.59
- MDL number: MFCD31630815
- Update Date: 2024-11-15 19:19:13
What is L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-?
Description
E3 Ligase ligand 1a is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein. E3 Ligase ligand 1a can be used to synthesize ARV-771, a BET PROTAC degrader.
The Uses of L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-
(4R)-3-Methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-L-prolinamide, is a ligand of E3 ligase,
Properties of L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-
Boiling point: | 687.9±55.0 °C(Predicted) |
Density | 1.233±0.06 g/cm3(Predicted) |
storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
pka | 14.00±0.40(Predicted) |
form | Solid |
color | White to yellow |
Safety information for L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-
Computed Descriptors for L-Prolinamide, 3-methyl-L-valyl-4-hydroxy-N-[(1S)-1-[4-(4-methyl-5-thiazolyl)phenyl]ethyl]-, (4R)-
InChIKey | JOSFQWNOUSNZBP-UUZHKXTQSA-N |
SMILES | C(N[C@H](C1=CC=C(C2SC=NC=2C)C=C1)C)(=O)[C@@H]1C[C@@H](O)CN1C(=O)[C@H](C(C)(C)C)N |
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2-(2,6-dioxopiperidin-3-yl)-4-fluoroisoindoline-1,3-dione
(2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride
Protein degrader 1 (TFA)
4-Hydroxy ThalidoMide
Cereblon Ligand 1
rac-((2R,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-4-phenylbutanoyl)-D-leucine
E3 ligase Ligand 14
E3 ligase Ligand 10
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