Cereblon Ligand 1
- CAS NO.：1061605-21-7
- Empirical Formula: C15H12N2O7
- Molecular Weight: 332.27
- MDL number: MFCD31560477
- Update Date: 2024-11-20 11:41:24
What is Cereblon Ligand 1?
Description
Thalidomide-Acid is a linker of Thalidomide which is commonly used as a precursor to PROTAC that hijacks cereblon as the E3 ubiquitin ligase component.
The Uses of Cereblon Ligand 1
Thalidomide-4-hydroxyacetate is a proteolysis targeting chimeras which allows for the optical control of protein degradation.
Solubility in organics
DMF: 30 mg/ml
DMSO: 30 mg/ml
PBS (pH 7.2): 1 mg/ml
storage
Store at RT
Properties of Cereblon Ligand 1
| Boiling point: | 660.5±55.0 °C(Predicted) |
| Density | 1.606±0.06 g/cm3(Predicted) |
| solubility | Soluble in DCM |
| pka | 2.95±0.10(Predicted) |
| form | A crystalline solid |
| color | White to off-white |
| InChI | InChI=1S/C15H12N2O7/c18-10-5-4-8(13(21)16-10)17-14(22)7-2-1-3-9(12(7)15(17)23)24-6-11(19)20/h1-3,8H,4-6H2,(H,19,20)(H,16,18,21) |
Safety information for Cereblon Ligand 1
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Cereblon Ligand 1
| InChIKey | ZVWIXIGBWIEDFO-UHFFFAOYSA-N |
| SMILES | C(O)(=O)COC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O |
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