L-KYNURENINE

Synonym(s):β-Anthraniloyl-L-alanine;L-2-Amino-4-(2-aminophenyl)-4-oxobutanoic acid

CAS NO.：2922-83-0
Empirical Formula: C10H12N2O3
Molecular Weight: 208.21
MDL number: MFCD00069912
SAFETY DATA SHEET (SDS)
Update Date: 2024-08-28 13:53:25

What is L-KYNURENINE?

Description

Kynurenine (2922-83-0) is a tryptophan catabolite.1?Endogenous tumor-promoting ligand of the human aryl hydrocarbon receptor (AhR). Constitutively generated by human tumor cells via the action of the tryptophan degrading enzyme, tryptophan-2,3-dioxygenase (TDO). Kynurenine suppresses antitumor immune responses and promotes tumor cell survival and motility.2

The Uses of L-KYNURENINE

L-Kynurenine has been used as a standard for indoleamine-2,3-dioxygenase (IDO) assay. It has also been used as a standard to extract and quantify kynurenine from cultured cells and media.

What are the applications of Application

L-Kynurenine is an intermediate able to suppress the antitumor immune response

Definition

ChEBI: A kynurenine that has L configuration.

Biochem/physiol Actions

Key intermediate in the breakdown pathway of tryptophan.

storage

Store at RT

References

References/Citations 1) Ibana?et al. (2011),?Inhibition of indoleamine 2,3-dioxygenase activity by levo-1-methyl tryptophan blocks gamma interferon-induced Chlaydia trachomatis persistence in human epithelial cells; Infect. Immun.,?79?4425 2) Opitz?et al. (2011),?An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor; Nature,?478?197

Properties of L-KYNURENINE

Melting point:	219 °C
Boiling point:	466.6±45.0 °C(Predicted)
Density	1.343±0.06 g/cm3(Predicted)
refractive index	-33 ° (C=0.4, H2O)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Soluble in DMSO (up to 2 mg/ml) or in Water (up to 2 mg/ml).
form	crystalline
pka	2.21±0.23(Predicted)
color	light yellow
Merck	14,5328
Stability:	Stable for 2 years as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 3 months.
CAS DataBase Reference	2922-83-0(CAS DataBase Reference)

Safety information for L-KYNURENINE

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.