L-CYCLOSERINE
Synonym(s):(S)-4-Amino-3-isoxazolidone
- CAS NO.:339-72-0
- Empirical Formula: C3H6N2O2
- Molecular Weight: 102.09
- MDL number: MFCD00064324
- EINECS: 206-427-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 21:13:59
What is L-CYCLOSERINE?
Chemical properties
WHITE GRANULAR POWDER
The Uses of L-CYCLOSERINE
L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase.
The Uses of L-CYCLOSERINE
antibacterial, coccidiostat
What are the applications of Application
L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase
Definition
ChEBI: A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora.
Biochem/physiol Actions
L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis.
Purification Methods
Purify cycloserine by recrystallisation from aqueous EtOH or MeOH or aqueous NH3/EtOH or isoPrOH. Also recrystallise it from aqueous ammoniacal solution at pH 10.5 (100mg/mL) by diluting with 5 volumes of isopropanol and then adjusting to pH 6 with acetic acid. An aqueous solution, buffered to pH 10 with Na2CO3, can be stored in a refrigerator for 1week without decomposition. UV: max at 226nm (A1cm 1% 4.02). The tartrate salt has m 165-166o (dec), 166-168o (dec), and [] D 24 -41o (c 0.7, H2O). [Stammer et al. J Am Chem Soc 79 3236 1959, UV: Kuehl J Am Chem Soc 77 2344 1955, Beilstein 27 III/IV 5549.]
Properties of L-CYCLOSERINE
Melting point: | 147 °C |
Boiling point: | 191.38°C (rough estimate) |
Density | 1.278 |
refractive index | 1.5110 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
solubility | H2O: soluble50mg/mg protein |
form | White to off-white powder. |
pka | 14.36±0.40(Predicted) |
color | White to Off-White |
BRN | 80799 |
CAS DataBase Reference | 339-72-0(CAS DataBase Reference) |
Safety information for L-CYCLOSERINE
Signal word | Warning |
Pictogram(s) |
Flame Flammables GHS02 |
GHS Hazard Statements |
H226:Flammable liquids |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P240:Ground/bond container and receiving equipment. P241:Use explosion-proof electrical/ventilating/lighting/…/equipment. P242:Use only non-sparking tools. P243:Take precautionary measures against static discharge. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P370+P378:In case of fire: Use … for extinction. P403+P235:Store in a well-ventilated place. Keep cool. |
Computed Descriptors for L-CYCLOSERINE
Abamectin manufacturer
JSK Chemicals
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