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HomeProduct name listL-CYCLOSERINE

L-CYCLOSERINE

Synonym(s):(S)-4-Amino-3-isoxazolidone

  • CAS NO.:339-72-0
  • Empirical Formula: C3H6N2O2
  • Molecular Weight: 102.09
  • MDL number: MFCD00064324
  • EINECS: 206-427-0
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
L-CYCLOSERINE Structural

What is L-CYCLOSERINE?

Chemical properties

WHITE GRANULAR POWDER

The Uses of L-CYCLOSERINE

L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase.

The Uses of L-CYCLOSERINE

antibacterial, coccidiostat

What are the applications of Application

L-Cycloserine is an irreversible inhibitor of 3-ketodihydrosphingosine synthetase

Definition

ChEBI: A 4-amino-1,2-oxazolidin-3-one that has S configuration. An antibiotic isolated from Erwinia uredovora.

Biochem/physiol Actions

L-cycloserine is a potent inhibitor of serine palmitoyltransferase, the first step of sphingolipid synthesis.

Purification Methods

Purify cycloserine by recrystallisation from aqueous EtOH or MeOH or aqueous NH3/EtOH or isoPrOH. Also recrystallise it from aqueous ammoniacal solution at pH 10.5 (100mg/mL) by diluting with 5 volumes of isopropanol and then adjusting to pH 6 with acetic acid. An aqueous solution, buffered to pH 10 with Na2CO3, can be stored in a refrigerator for 1week without decomposition. UV: max at 226nm (A1cm 1% 4.02). The tartrate salt has m 165-166o (dec), 166-168o (dec), and [] D 24 -41o (c 0.7, H2O). [Stammer et al. J Am Chem Soc 79 3236 1959, UV: Kuehl J Am Chem Soc 77 2344 1955, Beilstein 27 III/IV 5549.]

Properties of L-CYCLOSERINE

Melting point: 147 °C
Boiling point: 191.38°C (rough estimate)
Density  1.278
refractive index  1.5110 (estimate)
storage temp.  Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility  H2O: soluble50mg/mg protein
form  White to off-white powder.
pka 14.36±0.40(Predicted)
color  White to Off-White
BRN  80799
CAS DataBase Reference 339-72-0(CAS DataBase Reference)

Safety information for L-CYCLOSERINE

Signal word Warning
Pictogram(s)
ghs
Flame
Flammables
GHS02
GHS Hazard Statements H226:Flammable liquids
Precautionary Statement Codes P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233:Keep container tightly closed.
P240:Ground/bond container and receiving equipment.
P241:Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242:Use only non-sparking tools.
P243:Take precautionary measures against static discharge.
P280:Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P370+P378:In case of fire: Use … for extinction.
P403+P235:Store in a well-ventilated place. Keep cool.

Computed Descriptors for L-CYCLOSERINE

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