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HomeProduct name listL-4,4'-BIPHENYLALANINE

L-4,4'-BIPHENYLALANINE

L-4,4'-BIPHENYLALANINE Structural

What is L-4,4'-BIPHENYLALANINE?

Description

4-Biphenylyl-L-alanine (BipA) is a synthetic amino acid that was prepared to put a?“leash” on genetically modified?Escherichia coli.?It replaces phenylalanine in the codon of unmodified?E. coli. Additional phenylalanine derivatives have been made for the same purpose.
G. M. Church at Harvard Medical School and F. J. Isaacs at Yale University are using?E. coli?as a model to explore ways to prevent genetically modified organisms (GMOs) from reproducing in the environment. Tagging a GMO with a non-natural amino acid such as BipA allows it to reproduce in the laboratory but not in nature. If this strategy is successful, the next step would be to extend it to commercial GMOs such as crop plants.

The Uses of L-4,4'-BIPHENYLALANINE

L-4,4''-Biphenylalanine is a useful reagent in the preparation of other biologically active small molecules.

Properties of L-4,4'-BIPHENYLALANINE

Melting point: 227° - 229°C
Boiling point: 428.6±40.0 °C(Predicted)
Density  1.190±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,Room Temperature
solubility  Acidic DMSO (Slightly)
form  Solid
pka 2.21±0.10(Predicted)
color  White to Off-White
Stability: Hygroscopic
CAS DataBase Reference 155760-02-4(CAS DataBase Reference)

Safety information for L-4,4'-BIPHENYLALANINE

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for L-4,4'-BIPHENYLALANINE

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