KRN7000
Synonym(s):α-Galactosyl Ceramide;α-Galactosylceramide;α-GalCer;KRN7000
- CAS NO.：158021-47-7
- Empirical Formula: C50H99NO9
- Molecular Weight: 858.32
- MDL number: MFCD00939559
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-08 20:21:46
What is KRN7000?
Description
KRN 7000 is a potent synthetic α-
Chemical properties
White Solid
The Uses of KRN7000
Galactosylceramides play an important roles in promoting the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. It has shown to have significant immunostimulatory and anti-umor activity
The Uses of KRN7000
KRN 7000 is a potent synthetic α-galactosylceramide, which, in association with the antigen-presenting CD1d protein, activates NKT immune cells. As these cells have important roles in the rejection of malignant tumors and in the regulation of several autoimmune diseases, KRN 7000 has activity in many diseases, including cancer, lupus, diabetes, malaria, and tuberculosis.
The Uses of KRN7000
Galactosylceramides play an important roles in promoting the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. It has shown to have significant immunostimulatory and anti-umor activity in mice with liver metastasis of the Colon26 adenocarcinoma.
Definition
ChEBI: A glycophytoceramide having an alpha-D-galactosyl residue at the O-1 position and a hexacosanoyl group attached to the nitrogen.
storage
-20°C
Properties of KRN7000
| Melting point: | 125-130°C |
| Boiling point: | 939.8±65.0 °C(Predicted) |
| Density | 1.04±0.1 g/cm3(Predicted) |
| storage temp. | -20°C Freezer |
| solubility | Pyridine (Slightly, Heated) |
| form | White solid. |
| pka | 12.92±0.70(Predicted) |
| color | White to Pale Beige |
| Stability: | Hygroscopic |
| CAS DataBase Reference | 158021-47-7 |
Safety information for KRN7000
Computed Descriptors for KRN7000
New Products
(S)-3-Aminobutanenitrile hydrochloride 4-Methylphenylacetic acid N-Boc-D-alaninol N-BOC-D/L-ALANINOL Tert-butyl bis(2-chloroethyl)carbamate 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin- 2(1H)-one Furan-2,5-Dicarboxylic Acid Tropic acid 1-Bromo-3,5-Di-Tert-Butylbenzene S-2-CHLORO PROPIONIC ACID ETHYL ISOCYANOACETATE 2-Bromo-1,3-Bis(Dimethylamino)Trimethinium Hexafluorophosphate 4-IODO BENZOIC ACID 3-NITRO-2-METHYL ANILINE 1-(2,4-DICHLOROPHENYL) ETHANAMINE (2-Hydroxyphenyl)acetonitrile 4-Bromopyrazole 2-(Cyanocyclohexyl)acetic acid 4-methoxy-3,5-dinitropyridine 1-(4-(aminomethyl)benzyl)urea hydrochloride 2-aminopropyl benzoate hydrochloride diethyl 2-(2-((tertbutoxycarbonyl)amino) ethyl)malonate tert-butyl 4- (ureidomethyl)benzylcarbamate Ethyl-2-chloro((4-methoxyphenyl)hydrazono)acetateRelated products of tetrahydrofuran
![1-O-[BETA-D-GALACTOPYRANOSYL]-N-HEXADECANOYL-DL-DIHYDRO-SPHINGOSINE](https://img.chemicalbook.in/CAS/GIF/108392-00-3.gif)
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