KM 11060
- CAS NO.：774549-97-2
- Empirical Formula: C19H17Cl2N3O2S
- Molecular Weight: 422.33
- MDL number: MFCD01524977
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-07-02 08:54:57
What is KM 11060?
The Uses of KM 11060
KM 11060 is a small molecular corrector of F508del CFTR trafficking, which has potential application in cystic fibrosis therapeutics.
What are the applications of Application
KM 11060 is it increases the amount functional CFTR at the plasma membrane
Biological Activity
Corrects F508del-CFTR trafficking; increases the amount of functional CFTR at the plasma membrane (~75%). Shown to inhibit PDE5 activity.
Properties of KM 11060
| storage temp. | Store at RT |
| solubility | Soluble to 100 mM in DMSO and to 10 mM in ethanol |
| form | Powder |
| color | White to off-white |
Safety information for KM 11060
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for KM 11060
New Products
Tubulysin C Tubulysin I Tubulysin A Potassium HMDS (1.0 M in THF) Diethyl Aluminium Cyanide (1.0 M in Toluene) 3-N-BOC-(S)-AMINO BUTYRONITRILE 2,2-Difluoropropanol 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 4,4-DIFLUOROCYCLOHEXANAMINE 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell Imeglimin Hydrochloride IH Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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