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HomeProduct name listKHELLIN

KHELLIN

Synonym(s):4,9-Dimethoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one

  • CAS NO.:82-02-0
  • Empirical Formula: C14H12O5
  • Molecular Weight: 260.24
  • MDL number: MFCD00005007
  • EINECS: 201-392-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-09 19:38:33
KHELLIN Structural

What is KHELLIN?

The Uses of KHELLIN

Khellin has been used as a reference standard for supercritical fluid extraction of khellin from Ammi visnaga L. fruits to understand the various medicinal effects of γ-Pyrones by reversed phase HPLC method.

The Uses of KHELLIN

vasodilator (coronary), photosensitizer

What are the applications of Application

Khellin is a dye with vasodilatory properties that can induce skin pigmentation upon exposure to UV light

Definition

ChEBI: Khellin is a furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator. It has a role as a vasodilator agent, a bronchodilator agent, an anti-asthmatic agent and a cardiovascular drug. It is an organic heterotricyclic compound, an oxacycle and a furanochromone. It is functionally related to a 5H-furo[3,2-g]chromen-5-one.

brand name

Ammivin (Marion Merrell Dow); Khelloyd (Hoechst-Roussel).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 26, p. 1672, 1983 DOI: 10.1021/jm00366a002

General Description

Khellin, is reported to be an efficient drug for treating vitiligo when combined with ultraviolet A irradiation.

Purification Methods

Crystallise khellin from H2O, MeOH, pet ether or Et2O. The hydrochloride has m 98o(dec) (from EtOH/HCl). [Beilstein 19 II 236, 19 III/IV 2816, 19/6 V 320.]

Properties of KHELLIN

Melting point: 150154°C
Boiling point: 180200°C0.05mm Hg
Density  1.1954 (rough estimate)
refractive index  1.4560 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), Methanol (Slightly)
form  crystalline
color  light yellow
Water Solubility  247.2g/L(25 ºC)
Merck  14,5309
BRN  263185
EPA Substance Registry System Khellin (82-02-0)

Safety information for KHELLIN

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for KHELLIN

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