KHELLIN
Synonym(s):4,9-Dimethoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one
- CAS NO.:82-02-0
- Empirical Formula: C14H12O5
- Molecular Weight: 260.24
- MDL number: MFCD00005007
- EINECS: 201-392-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-09 19:38:33
What is KHELLIN?
The Uses of KHELLIN
Khellin has been used as a reference standard for supercritical fluid extraction of khellin from Ammi visnaga L. fruits to understand the various medicinal effects of γ-Pyrones by reversed phase HPLC method.
The Uses of KHELLIN
vasodilator (coronary), photosensitizer
What are the applications of Application
Khellin is a dye with vasodilatory properties that can induce skin pigmentation upon exposure to UV light
Definition
ChEBI: Khellin is a furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator. It has a role as a vasodilator agent, a bronchodilator agent, an anti-asthmatic agent and a cardiovascular drug. It is an organic heterotricyclic compound, an oxacycle and a furanochromone. It is functionally related to a 5H-furo[3,2-g]chromen-5-one.
brand name
Ammivin (Marion Merrell Dow); Khelloyd (Hoechst-Roussel).
Synthesis Reference(s)
Journal of Medicinal Chemistry, 26, p. 1672, 1983 DOI: 10.1021/jm00366a002
General Description
Khellin, is reported to be an efficient drug for treating vitiligo when combined with ultraviolet A irradiation.
Purification Methods
Crystallise khellin from H2O, MeOH, pet ether or Et2O. The hydrochloride has m 98o(dec) (from EtOH/HCl). [Beilstein 19 II 236, 19 III/IV 2816, 19/6 V 320.]
Properties of KHELLIN
Melting point: | 150154°C |
Boiling point: | 180200°C0.05mm Hg |
Density | 1.1954 (rough estimate) |
refractive index | 1.4560 (estimate) |
storage temp. | Sealed in dry,Room Temperature |
solubility | Chloroform (Slightly), Methanol (Slightly) |
form | crystalline |
color | light yellow |
Water Solubility | 247.2g/L(25 ºC) |
Merck | 14,5309 |
BRN | 263185 |
EPA Substance Registry System | Khellin (82-02-0) |
Safety information for KHELLIN
Signal word | Danger |
Pictogram(s) |
Skull and Crossbones Acute Toxicity GHS06 |
GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for KHELLIN
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