Contact us: +91 9550333722 040 - 40102781
Structured search
India
Choose your country
Different countries will display different contents
Try our best to find the right business for you.
My chemicalbook

Welcome back!

HomeProduct name listKHELLIN

KHELLIN

Synonym(s):4,9-Dimethoxy-7-methyl-5H-furo[3,2-g][1]benzopyran-5-one

  • CAS NO.:82-02-0
  • Empirical Formula: C14H12O5
  • Molecular Weight: 260.24
  • MDL number: MFCD00005007
  • EINECS: 201-392-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-19 20:33:22
KHELLIN Structural

What is KHELLIN?

The Uses of KHELLIN

Khellin has been used as a reference standard for supercritical fluid extraction of khellin from Ammi visnaga L. fruits to understand the various medicinal effects of γ-Pyrones by reversed phase HPLC method.

The Uses of KHELLIN

vasodilator (coronary), photosensitizer

What are the applications of Application

Khellin is a dye with vasodilatory properties that can induce skin pigmentation upon exposure to UV light

Definition

ChEBI: Khellin is a furanochrome in which the basic tricyclic skeleton is substituted at positions 4 and 9 with methoxy groups and at position 7 with a methyl group. A major constituent of the plant Ammi visnaga it is a herbal folk medicine used for various illnesses, its main effect being as a vasodilator. It has a role as a vasodilator agent, a bronchodilator agent, an anti-asthmatic agent and a cardiovascular drug. It is an organic heterotricyclic compound, an oxacycle and a furanochromone. It is functionally related to a 5H-furo[3,2-g]chromen-5-one.

brand name

Ammivin (Marion Merrell Dow); Khelloyd (Hoechst-Roussel).

Synthesis Reference(s)

Journal of Medicinal Chemistry, 26, p. 1672, 1983 DOI: 10.1021/jm00366a002

General Description

Khellin, is reported to be an efficient drug for treating vitiligo when combined with ultraviolet A irradiation.

Purification Methods

Crystallise khellin from H2O, MeOH, pet ether or Et2O. The hydrochloride has m 98o(dec) (from EtOH/HCl). [Beilstein 19 II 236, 19 III/IV 2816, 19/6 V 320.]

Properties of KHELLIN

Melting point: 150154°C
Boiling point: 180200°C0.05mm Hg
Density  1.1954 (rough estimate)
refractive index  1.4560 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Chloroform (Slightly), Methanol (Slightly)
form  crystalline
color  light yellow
Water Solubility  247.2g/L(25 ºC)
Merck  14,5309
BRN  263185
EPA Substance Registry System Khellin (82-02-0)

Safety information for KHELLIN

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for KHELLIN

Related products of tetrahydrofuran

You may like

Statement: All products displayed on this website are only used for non medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.