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HomeProduct name listKETANSERIN TARTRATE

KETANSERIN TARTRATE

Synonym(s):3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt;5-HT 2A Serotonin Receptor Antagonist, Ketanserin, R 41 468;Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem;R 41468 (+)-tartrate salt

  • CAS NO.:83846-83-7
  • Empirical Formula: C26H28FN3O9
  • Molecular Weight: 545.52
  • MDL number: MFCD11864992
  • EINECS: 281-062-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-18 21:14:07
KETANSERIN TARTRATE Structural

What is KETANSERIN TARTRATE?

Description

Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT2 (IC50 = 6.3 nM; Ki = 2.1 nM). It has no activity at 5-HT1 receptors but does have activity at histamine type 1, α1-adrenergic, and dopamine receptors with Ki values of 10, 10, and 220 nM, respectively. Ketanserin induces dose-dependent inhibition of contractile responses to 5-HT in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins. Ketanserin (10 mg/kg/day) significantly decreases blood pressure (BP), blood pressure variability (BPV), and hypertensive organ damage in spontaneously hypertensive rats. Formulations containing ketanserin have been used to treat hypertension in early-onset preeclampsia.

The Uses of KETANSERIN TARTRATE

coccidiostat

The Uses of KETANSERIN TARTRATE

Selective 5-HT2A serotonin receptor antagonist

What are the applications of Application

Ketanserin tartrate is a selective serotonin agonist

Biological Activity

Selective 5-HT 2A serotonin receptor antagonist; can also be used to discriminate between 5-HT 1D and 5-HT 1B receptor subtypes.

Biochem/physiol Actions

Selective 5-HT2 serotonin receptor antagonist. Ketanserin significantly reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction.

storage

Room temperature

Properties of KETANSERIN TARTRATE

Melting point: 183~186℃
storage temp.  2-8°C
solubility  ethanol: 3.3mg/mL
form  solid
color  white
Water Solubility  Soluble to 10 mM in water
CAS DataBase Reference 83846-83-7(CAS DataBase Reference)

Safety information for KETANSERIN TARTRATE

Signal word Danger
Pictogram(s)
ghs
Skull and Crossbones
Acute Toxicity
GHS06
GHS Hazard Statements H301:Acute toxicity,oral
Precautionary Statement Codes P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Computed Descriptors for KETANSERIN TARTRATE

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