KETANSERIN TARTRATE
Synonym(s):3-(2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl)-2,4(1H,3H)-quinazolinedione (+)-tartrate salt;5-HT 2A Serotonin Receptor Antagonist, Ketanserin, R 41 468;Ketanserin Tartrate - CAS 83846-83-7 - Calbiochem;R 41468 (+)-tartrate salt
- CAS NO.：83846-83-7
- Empirical Formula: C26H28FN3O9
- Molecular Weight: 545.52
- MDL number: MFCD11864992
- EINECS: 281-062-8
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-30 15:45:59
What is KETANSERIN TARTRATE?
Description
Ketanserin is a potent antagonist of the serotonin (5-HT) receptor that is selective for 5-HT2 (IC50 = 6.3 nM; Ki = 2.1 nM). It has no activity at 5-HT1 receptors but does have activity at histamine type 1, α1-adrenergic, and dopamine receptors with Ki values of 10, 10, and 220 nM, respectively. Ketanserin induces dose-dependent inhibition of contractile responses to 5-HT in isolated rat caudal artery, canine basilar, carotid, coronary and gastrosplenic arteries, and canine gastrosplenic and saphenous veins. Ketanserin (10 mg/kg/day) significantly decreases blood pressure (BP), blood pressure variability (BPV), and hypertensive organ damage in spontaneously hypertensive rats. Formulations containing ketanserin have been used to treat hypertension in early-onset preeclampsia.
The Uses of KETANSERIN TARTRATE
Selective 5-HT2A serotonin receptor antagonist
The Uses of KETANSERIN TARTRATE
coccidiostat
What are the applications of Application
Ketanserin tartrate is a selective serotonin agonist
Biological Activity
Selective 5-HT 2A serotonin receptor antagonist; can also be used to discriminate between 5-HT 1D and 5-HT 1B receptor subtypes.
Biochem/physiol Actions
Selective 5-HT2 serotonin receptor antagonist. Ketanserin significantly reduces nicotine self-administration in rats, supporting an unexpected involvement of serotonin in nicotine addiction.
storage
Room temperature
Properties of KETANSERIN TARTRATE
| Melting point: | 183～186℃ |
| storage temp. | 2-8°C |
| solubility | ethanol: 3.3mg/mL |
| form | solid |
| color | white |
| Water Solubility | Soluble to 10 mM in water |
| CAS DataBase Reference | 83846-83-7(CAS DataBase Reference) |
Safety information for KETANSERIN TARTRATE
| Signal word | Danger |
| Pictogram(s) |
 Skull and Crossbones Acute Toxicity GHS06 |
| GHS Hazard Statements |
H301:Acute toxicity,oral |
| Precautionary Statement Codes |
P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for KETANSERIN TARTRATE
New Products
(2S,4R)-4-amino-2-methyl-5-phenylpentanoic acid hydrochloride Tubulysin F Tubulysin B 2,2-diethoxyethanethioamide Tubulysin G 3-METHYLAZETIDIN-3-OL HYDROCHLORIDE 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE 2H-Pyran, 4-ethynyltetrahydro- 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) 1-(1,1-Difluoroethyl)-2-fluorobenzene Isoxazole, 3-[[[5-(difluoromethoxy)-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]methyl]thio]-4,5-dihydro-5,5-dimethyl- Fuel shell Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile Imeglimin Hydrochloride IH Latanoprostene Bunod Magnesium Trisilicate Lubiprostone Flame Retardant Zinc Borate (R)-(3-(3-fluoro-4- thiomorpholinophenyl)-2- oxooxazolidin-4-yl) methyl methanesulfonate methyl 3-fluoro-4- thiomorpholino phenylcarbamate 7-Methoxyquinoline-4-carboxylic acidRelated products of tetrahydrofuran
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