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HomeProduct name listKetanserin

Ketanserin

  • CAS NO.:74050-98-9
  • Empirical Formula: C22H22FN3O3
  • Molecular Weight: 395.43
  • MDL number: MFCD00083392
  • EINECS: 277-680-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 19:05:58
Ketanserin Structural

What is Ketanserin?

Description

Ketanserin is an antihypertensive agent with antagonist properties at both the serotonin-S2 and α1-adrenergic receptors. Its mechanism of action, while still controversial, may involve interactions at both of these loci.

Chemical properties

Off-White Solid

Originator

Janssen (Belgium)

The Uses of Ketanserin

An antihypertensive, with affinity for multiple GPCR receptors.

The Uses of Ketanserin

receptor antagonist

What are the applications of Application

Ketanserin is a selective serotonin antagonist

Definition

ChEBI: A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.

brand name

SEREFREX

Purification Methods

It has been purified by recrystallisation from 4-methyl-3-pentanone [Peeters et al. Cryst Structure Commun 11 375 1982, Kacprowicz et al. J Chromatogr 272 417 1983, Davies et al. J Chromatogr 275 232 1983]. It is an antihypertensive.

Properties of Ketanserin

Melting point: 227-235°C
Density  1.280±0.06 g/cm3(Predicted)
storage temp.  Sealed in dry,2-8°C
solubility  DMF: 10 mg/mL, clear, colorless
pka 7.5(at 25℃)
form  Solid
color  White to Off-White
Merck  14,5296
CAS DataBase Reference 74050-98-9(CAS DataBase Reference)

Safety information for Ketanserin

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H302:Acute toxicity,oral
Precautionary Statement Codes P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.

Computed Descriptors for Ketanserin

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