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HomeProduct name listISOXANTHOHUMOL

ISOXANTHOHUMOL

Synonym(s):2,3-Dihydro-7-hydroxy-2-(4-hydroxyphenyl)-5-methoxy-8-(3-methyl-2-butenyl)-4H-1-benzopyran-4-one;4,7-Dihydroxy-5-methoxy-8-prenylflavanone;Humulol;Isoxanthohumol;IXN

ISOXANTHOHUMOL Structural

What is ISOXANTHOHUMOL?

Description

Isoxanthohumol is a natural, prenylated chalcone isolated from the hop plant, H. lupulus (hops). It has diverse biological activities, including antiproliferative, anti-inflammatory, and antiviral properties. In B16 and A375 melanoma cells, isoxanthohumol inhibits proliferation (IC50s = 22.15 and 22.9 μM in an MTT assay), slows cell division, and induces apoptosis. Isoxanthohumol reversibly inhibits Kv1.3 channels with an EC50 value of 7.8 μM in human Jurkat T cells using patch clamp electrophysiology. It has strong deterrent properties against the peach potato aphid. It has also been used as a marker of beer consumption. Isoxanthohumol is metabolized in the liver and intestine to 8-prenylnaringenin , a potent phytoestrogen.

The Uses of ISOXANTHOHUMOL

Isoxanthohumol is a prenylated flavone isolated from hop. A chromane-like cyclic prenylflavonoids for neurological disorder therapy. Isoxanthohumol is a prenylated flavonoid phytoestrogen which is an apoptosis inducer in mature adipocytes

What are the applications of Application

Isoxanthohumol is a prenylated flavonoid Phytoestrogen which is an apoptosis inducer in mature adipocytes

Definition

ChEBI: Isoxanthohumol is a member of flavanones.

Properties of ISOXANTHOHUMOL

Melting point: 183 - 187°
Boiling point: 585.8±50.0 °C(Predicted)
Density  1.245±0.06 g/cm3(Predicted)
storage temp.  2-8°C
solubility  DMSO (Slightly), Methanol (Slightly)
form  powder
pka 7.90±0.40(Predicted)
color  Pale Yellow
BRN  10199264

Safety information for ISOXANTHOHUMOL

Computed Descriptors for ISOXANTHOHUMOL

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