Isovaleryl chloride

Synonym(s):3-Methylbutyryl chloride

CLEAR COLOURLESS TO SLIGHTLY YELLOW OR PINK LIQUID

Isovaleryl chloride was used in the synthesis of:

furanodictines A and B
tetrapeptide amide, S-benzyl-L-cysteinyl-L-prolyl-L-leucylglycinamide
(+)-blastmycinone
(R)- and (S)-2-methyl-4-octanol, aggregation pheromone of some sugarcane weevils

Isovaleryl chloride is an acid halide and amino acid analog and potentially useful synthetic reagent

Journal of the American Chemical Society, 69, p. 2917, 1947 DOI: 10.1021/ja01203a514

Highly flammable

Boiling point:	115-117 °C (lit.)
Density	0.989 g/mL at 25 °C (lit.)
vapor pressure	20.3hPa at 20℃
refractive index	n20/D 1.416(lit.)
Flash point:	66 °F
storage temp.	Flammables area
solubility	Chloroform (Soluble), Methanol (Slightly)
form	Liquid
color	Clear colorless to slightly yellow or pink
Water Solubility	decomposes
Sensitive	Moisture Sensitive
Merck	14,5232
BRN	741910
Stability:	Moisture Sensitive
CAS DataBase Reference	108-12-3(CAS DataBase Reference)
NIST Chemistry Reference	Butanoyl chloride, 3-methyl-(108-12-3)
EPA Substance Registry System	Butanoyl chloride, 3-methyl- (108-12-3)

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Corrosion Corrosives GHS05 Skull and Crossbones Acute Toxicity GHS06
GHS Hazard Statements	H226:Flammable liquids H314:Skin corrosion/irritation H331:Acute toxicity,inhalation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P233:Keep container tightly closed. P280:Wear protective gloves/protective clothing/eye protection/face protection. P303+P361+P353:IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.