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HomeProduct name listIsosorbide dimethyl ether

Isosorbide dimethyl ether

Synonym(s):DMI;Dimethyl isosorbide;Isosorbide dimethyl ether;1,4:3,6-Dianhydro-2,5-di-O-methyl-D-glucitol;1,4:3,6-Dianhydrosorbitol 2,5-dimethyl ether

  • CAS NO.:5306-85-4
  • Empirical Formula: C8H14O4
  • Molecular Weight: 174.2
  • MDL number: MFCD00064828
  • EINECS: 226-159-8
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-10-30 18:52:02
Isosorbide dimethyl ether Structural

What is Isosorbide dimethyl ether?

Chemical properties

clear colorless to light yellow liquid. very stable under neutral conditions, hygroscopic and miscible with most organic solvents.

The Uses of Isosorbide dimethyl ether

Isosorbide dimethyl ether (DMI), a sustainable solvent, is widely used in various cosmetic and pharmaceutical formulations.
General applications:
DMI can be used as an alternative green solvent for epoxidation of cyclooctene, Baylis–Hillman reaction of isomaltulose-derived aldehydes with α,β-unsaturated ketones and also in solid-phase synthesis.
It can be used as a coalescent for water-borne paints, where it acts as a co-solvent during the water loss phase and as a coalescing agent during the film formation.

The Uses of Isosorbide dimethyl ether

dimethyl isosorbide is a carrier, solvent, and viscosity controller. Its particular skin-penetrating ability opens the possibility of enhancing active substance efficacy in optical products. Its physical characteristics and solubility properties are superior to those of propylene glycol, glycerin, or ethyl alcohol.

What are the applications of Application

Isosorbide dimethyl ether is a speciality solvent

Preparation

Isosorbide dimethyl ether is synthesized from isosorbide by methylation.
Isosorbide dimethyl ether is obtained from stock like D-sorbitol, which is mainly derived from the hydrogenation of D-glucose.
Isosorbide dimethyl has a low level of toxicity and is referred to as a green solvent due to its production from renewable/raw material.
The boiling point of this solvent is high.
lt is used as a substitute to dimethyl sulfoxide,and dimethylformamide-like solvents.

General Description

Dimethyl isosorbide (DMI) is a biobased greener solvent and thus aligns with "Use of Renewable Feedstocks" and "Safer Solvents and Auxiliaries".

Flammability and Explosibility

Non flammable

Properties of Isosorbide dimethyl ether

Melting point: -70°C
Boiling point: 93-95 °C0.1 mm Hg(lit.)
Density  1.15 g/mL at 25 °C(lit.)
vapor pressure  12.54Pa at 20℃
refractive index  n20/D 1.461(lit.)
Flash point: 227 °F
storage temp.  Sealed in dry,Room Temperature
form  Liquid
color  Clear colorless to light yellow
PH 7.0-8.0 (100g/l, H2O, 20℃)
optical activity [α]21/D +96.1°, c = 2 in chloroform
Water Solubility  Soluble in water.
BRN  80854
CAS DataBase Reference 5306-85-4(CAS DataBase Reference)

Safety information for Isosorbide dimethyl ether

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
Precautionary Statement Codes P280:Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352:IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313:IF SKIN irritation occurs: Get medical advice/attention.
P337+P313:IF eye irritation persists: Get medical advice/attention.

Computed Descriptors for Isosorbide dimethyl ether

InChIKey MEJYDZQQVZJMPP-ULAWRXDQSA-N

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