ISOGUVACINE HYDROCHLORIDE
Synonym(s):1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
- CAS NO.：64603-90-3
- Empirical Formula: C6H9NO2
- Molecular Weight: 127.14
- MDL number: MFCD00055192
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:41
What is ISOGUVACINE HYDROCHLORIDE?
Description
This base is isolated, together with Guvacine (q.v.) from the nuts of Areca catechu. It is optically inactive and yields crystalline salts: the hydrochloride, m.p. 231°C; aurich1oride, m.p. 198- 200°C and the p1atinich1oride, m.p. 235°C. The alkaloid is faintly acid to litmus and on methylation gives the N-methyl derivative which, on more vigorous methylation yields the dimethyl compound giving a crystalline platinichloride, m.p. 252°C. The above melting points suggest that the base may be mainly Arecaidine (q.v.) but on distillation with Zn dust, it yields products with the characteristic pyrrole reaction.
Chemical properties
bp 195-197°C
The Uses of ISOGUVACINE HYDROCHLORIDE
A GABAA receptor agonist. Anticonvulsant; antiepileptic.
Definition
ChEBI: Isoguvacine is a tetrahydropyridine.
Biological Activity
Specific GABA A receptor agonist.
References
Jahns., Ber., 21,3404 (1888) Jahns., ibid, 23, 2972 (1890) Jahns., ibid, 24,2615 (1891) Jahns., Arch. Pharrn., 229, 669 (1891) Trier., Zeit. Physiol. Chern., 85,372 (1913)
Properties of ISOGUVACINE HYDROCHLORIDE
| Melting point: | 220 °C |
| Boiling point: | 280.8±35.0 °C(Predicted) |
| Density | 1.199±0.06 g/cm3(Predicted) |
| RTECS | US5908286 |
| storage temp. | Store at RT |
| solubility | H2O: refrigerate if not used immediately.soluble |
| form | solid |
| pka | pK1:9.07 (25°C) |
| color | white |
| Water Solubility | Soluble in water |
Safety information for ISOGUVACINE HYDROCHLORIDE
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up. |
Computed Descriptors for ISOGUVACINE HYDROCHLORIDE
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