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HomeProduct name listISOGUVACINE HYDROCHLORIDE

ISOGUVACINE HYDROCHLORIDE

Synonym(s):1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride

ISOGUVACINE HYDROCHLORIDE Structural

What is ISOGUVACINE HYDROCHLORIDE?

Description

This base is isolated, together with Guvacine (q.v.) from the nuts of Areca catechu. It is optically inactive and yields crystalline salts: the hydrochloride, m.p. 231°C; aurich1oride, m.p. 198- 200°C and the p1atinich1oride, m.p. 235°C. The alkaloid is faintly acid to litmus and on methylation gives the N-methyl derivative which, on more vigorous methylation yields the dimethyl compound giving a crystalline platinichloride, m.p. 252°C. The above melting points suggest that the base may be mainly Arecaidine (q.v.) but on distillation with Zn dust, it yields products with the characteristic pyrrole reaction.

Chemical properties

bp 195-197°C

The Uses of ISOGUVACINE HYDROCHLORIDE

A GABAA receptor agonist. Anticonvulsant; antiepileptic.

Definition

ChEBI: Isoguvacine is a tetrahydropyridine.

Biological Activity

Specific GABA A receptor agonist.

References

Jahns., Ber., 21,3404 (1888) Jahns., ibid, 23, 2972 (1890) Jahns., ibid, 24,2615 (1891) Jahns., Arch. Pharrn., 229, 669 (1891) Trier., Zeit. Physiol. Chern., 85,372 (1913)

Properties of ISOGUVACINE HYDROCHLORIDE

Melting point: 220 °C
Boiling point: 280.8±35.0 °C(Predicted)
Density  1.199±0.06 g/cm3(Predicted)
RTECS  US5908286
storage temp.  Store at RT
solubility  H2O: refrigerate if not used immediately.soluble
form  solid
pka pK1:9.07 (25°C)
color  white
Water Solubility  Soluble in water

Safety information for ISOGUVACINE HYDROCHLORIDE

Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H315:Skin corrosion/irritation
H319:Serious eye damage/eye irritation
H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405:Store locked up.

Computed Descriptors for ISOGUVACINE HYDROCHLORIDE

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