isoaminile
- CAS NO.:77-51-0
- Empirical Formula: C16H24N2
- Molecular Weight: 244.38
- EINECS: 201-033-5
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-04 17:34:42
What is isoaminile?
Originator
Peracon,Toyo Jozo,Japan,1969
The Uses of isoaminile
Treatment of rheumatoid arthritis.
Background
Isoaminile, an antitussive drug with a structure similar to methadone, is also an anticholinergic with both antimuscarinic and antinicotinic properties.
Definition
ChEBI: Isoaminile is an alkylbenzene.
Manufacturing Process
140 cc of benzene and 24 g of α-isopropyl phenyl acetonitrile are added to 7.5
g of sodium amide. The mixture is stirred and refluxed for one hour. After
cooling, 25 g of 2-dimethylamino-1-chloropropane, dissolved in 20 cc of
benzene, are added and stirring and refluxing of the mixture is continued for
4 hours. After the reaction is completed, water is added to the reaction
mixture. The benzene layer is separated from the aqueous layer and is
extracted by means of 4N hydrochloric acid. The acid solution is rendered
alkaline.
The separated oil is taken up in ether. After drying the ethereal solution over
sodium sulfate and distilling off the ether, the resulting crude α-isopropyl-α- (β'-dimethylamino propyl) phenyl acetonitrile is purified by distillation in a
vacuum. The compound boils at 138° to 146°C/3 mm, according to US Patent
2,934,557.
Therapeutic Function
Antitussive
Metabolism
Not Available
Properties of isoaminile
Boiling point: | bp3 138-146° |
Density | 1.0080 (rough estimate) |
refractive index | 1.5519 (estimate) |
storage temp. | -196°C |
pka | 9.02±0.50(Predicted) |
Safety information for isoaminile
Computed Descriptors for isoaminile
New Products
6-Bromo 2-Iodo Indole Pyridine 2,4,6-Tricarboxaldehyde Fosfomycin EP impurity D Rimegepant Impurity 3 Ivermectin EP Impurity B Tubulysin F Tubulysin M Tubulysin H Tubulysin D Tubulysin G 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 2-(1-(Mercaptomethyl) cyclopropyl) acetonitrile (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH Fuel shell Diethyl 2,5-di(furan-2-yl)terephthalate (1-Isopropyl-1H-pyrazol-5-yl)boronic acid 1-(4-Fluorophenyl)piperidin-2-one Methyl 4-amino-3-(piperidin-1-yl)benzoate 2-Ethoxy-4-nitrobenzoic acid 3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione 5-Bromo-4,6-difluoro-2,3-dihydro-1h-indole 3-HYDROXY-8-FLUORONAPHTHALENE-1-BORONIC ACID PINACOL ESTERRelated products of tetrahydrofuran
You may like
-
TAT-1 CASView Details
-
3,6-Bis(4-iodophenyl)-2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dioneView Details
952145-70-9 -
1262243-12-8View Details
1262243-12-8 -
Sidchem 730View Details
-
Sidchem BT 20View Details
-
1572177-89-9View Details
1572177-89-9 -
6390-09-6View Details
6390-09-6 -
6-Bromo indoleView Details