Isazophos

CAS NO.：42509-80-8
Empirical Formula: C9H17ClN3O3PS
Molecular Weight: 313.74
MDL number: MFCD00078699
EINECS: 255-863-8
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-04 17:34:38

What is Isazophos?

Description

Isazofos is a yellow liquid. Solubility in water is 168 mg/L (20 ?C). It is miscible with common organic solvents. Log Kow = 2.99. It is hydrolyzed in aqueous media: DT₅₀ values (20 ?C) at pH 5, 7, and 9 are 85, 48, and 19 d, respectively.

The Uses of Isazophos

Isazophos is an organophosphate pesticide.

The Uses of Isazophos

Nematocide; turf insecticide.

The Uses of Isazophos

Isazofos is used as a nematicide and soil insecticide in bananas, citrus, cotton, beet, maize, rice, vegetables, sugar cane and turf.

Definition

ChEBI: Isazofos is an organic thiophosphate.

Metabolic pathway

Isazofos is metabolised in soil to its hydrolysis product 5-chloro-1- isopropyl-3-triazolol. The oxon metabolite has apparently not been identified.

Metabolism

In mammals, administered isazofos is rapidly metabolized and excreted, primarily in the urine, without accumulation in the body. The degradation route of isazofos in soil is primarily the hydrolysis mediated by microorganisms to give 5-chloro-1-isopropyl-3-triazole. The half-life in soils is about 10 d.

Degradation

Isazofos is hydrolysed more rapidly in alkaline rather than acid solution. The DT₅₀ values at pH 5, 7 and 9 were 85, 48 and 19 days, respectively (PM).

Toxicity evaluation

Acute oral LD₅₀ for rats is 40–60 mg/kg. Inhalation LC50 (4 h) for rats is about 0.24 mg/L air. NOEL (90 d) for rats is 2 mg/kg diet (0.1 mg/kg/d).

Properties of Isazophos

Melting point:	<25℃
Boiling point:	bp0.001 100°; bp760 170°
Density	1.22 g/cm3 (20℃)
vapor pressure	7.45 x 10^-3 Pa (20 °C)
refractive index	nD20 1.4867
storage temp.	0-6°C
form	liquid
Water Solubility	168 mg l^-1 (20 °C)
pka	-1.47±0.10(Predicted)
BRN	8145294
EPA Substance Registry System	Isazofos (42509-80-8)

Safety information for Isazophos

Signal word	Danger
Pictogram(s)	Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 Environment GHS09
GHS Hazard Statements	H317:Sensitisation, Skin H373:Specific target organ toxicity, repeated exposure H410:Hazardous to the aquatic environment, long-term hazard
Precautionary Statement Codes	P262:Do not get in eyes, on skin, or on clothing. P273:Avoid release to the environment. P280:Wear protective gloves/protective clothing/eye protection/face protection. P314:Get medical advice/attention if you feel unwell.