irisolidone

CAS NO.：2345-17-7
Empirical Formula: C17H14O6
Molecular Weight: 314.29
SAFETY DATA SHEET (SDS)
Update Date: 2023-05-21 10:59:17

What is irisolidone?

Description

Irisolidone is a hydrolyzed product of kudzurin. Studies have shown that it can significantly dilate coronary arteries, cerebral arteries and peripheral blood vessels and microvessels, and can reduce vascular resistance, cholesterol and blood viscosity.

Chemical properties

Light yellow crystalline powder, soluble in methanol, ethanol, DMSO and other organic solvents, derived from kudzu.

The Uses of irisolidone

Irisolidone has anti-inflammatory, antioxidant, antibacterial, anti-tumor, estrogen-like effects, and protects liver damage caused by alcoholism.

Definition

ChEBI: Irisolidone is a member of 4'-methoxyisoflavones.

Biological Activity

Irisolidone is the main isoflavone in pueraria. Irisolidone has strong hepatoprotective activity. It has a highly effective blocking effect on the anion channel VRAC.

in vitro

Irisolidone shows the high efficacy for Volume-regulated anion channels (VRAC) blockade with an IC ₅₀ of 9.8 μM in HEK293 cells.
It can inhibit endothelial cell proliferation.

Properties of irisolidone

Melting point:	190-191 °C
Boiling point:	565.5±50.0 °C(Predicted)
Density	1.402±0.06 g/cm3(Predicted)
storage temp.	4°C, protect from light
solubility	Chloroform (Slightly), DMSO (Slightly)
form	Solid
pka	6.48±0.20(Predicted)
color	Off-White to Pale Yellow

Safety information for irisolidone

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P332+P313:IF SKIN irritation occurs: Get medical advice/attention. P337+P313:IF eye irritation persists: Get medical advice/attention.