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HomeProduct name listIpratropium bromide monohydrate

Ipratropium bromide monohydrate

Synonym(s):Atropine isopropyl bromide;Ipratropium bromide monohydrate

  • CAS NO.:66985-17-9
  • Empirical Formula: C20H32BrNO4
  • Molecular Weight: 430.38
  • MDL number: MFCD04108705
  • EINECS: 622-130-2
  • SAFETY DATA SHEET (SDS)
  • Update Date: 2024-11-05 08:26:49
Ipratropium bromide monohydrate Structural

What is Ipratropium bromide monohydrate?

Description

Ipratropium bromide is a quaternary ammonium congener of atropine and is an anticholinergic compound approved for use as a bronchodilator. Anticholinergic agents produce bronchodilatation by antagonizing the activity of acetylcholine at the level of its receptor, particularly those found on airway smooth muscle in the large, central airways. The onset of action of ipratropium is relatively slow (20 minutes), and the peak effect occurs at 60 minutes.1 Ipratropium, unlike atropine, is poorly absorbed across mucous membranes and has little toxicity at the usual doses.

Chemical properties

White or almost white, crystalline powder.

The Uses of Ipratropium bromide monohydrate

Ipratropium bromide monohydrate has been used for the inhibition of peripheral muscarinic receptors in rats.

The Uses of Ipratropium bromide monohydrate

antihypertensive

Definition

ChEBI: The monohydrate form of ipratropium bromide. An anticholinergic drug, ipratropium bromide blocks the muscarinic cholinergic receptors in the smooth muscles of the bronchi in the lungs. This opens the bronchi, so providing relief in chronic obstructive pulm nary disease and acute asthma.

brand name

Atrovent (Boehringer Ingelheim).

Biochem/physiol Actions

Ipratropium bromide monohydrate is a nonselective muscarinic acetylcholine receptor antagonist and a bronchodilator. In nebulized form, it is used for treating asthma and obstructive pulmonary diseases. It acts as a β2 adrenoreceptor agonist. Ipratropium bromide monohydrate is an anticholinergic agent and competes with acetylcholine. It promotes bronchodilation by stimulating sympathetic pathways.

Clinical Use

Anticholinergic bronchodilator:

Reversible airways obstruction, particularly in COPD

Side Effects

Previous severe allergic reaction symptoms upon using ipratropium or atropine and its other derivatives, such as angioedema, urticaria, severe shortness of breath, oropharyngeal edema, and ultimately anaphylaxis is a contraindication to ipratropium use.
Ipratropium aerosols can cause bronchospasms (paradoxical), which usually happens upon the initial use of this medication

Metabolism

After inhalation, around 10-30% of a dose is deposited in the lungs where it exerts its therapeutic effect. Only a small amount of ipratropium reaches the systemic circulation. The majority of a dose is swallowed but is poorly absorbed from the gastrointestinal tract. Ipratropium and its metabolites are eliminated in the urine and faeces.

Properties of Ipratropium bromide monohydrate

Melting point: 231 °C
storage temp.  2-8°C
solubility  H2O: soluble10mg/mL
form  powder
color  white
Stability: Hygroscopic

Safety information for Ipratropium bromide monohydrate

Signal word Warning
Pictogram(s)
ghs
Exclamation Mark
Irritant
GHS07
GHS Hazard Statements H319:Serious eye damage/eye irritation
Precautionary Statement Codes P261:Avoid breathing dust/fume/gas/mist/vapours/spray.
P264:Wash hands thoroughly after handling.
P264:Wash skin thouroughly after handling.
P270:Do not eat, drink or smoke when using this product.
P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Computed Descriptors for Ipratropium bromide monohydrate

InChIKey KEWHKYJURDBRMN-XSAPEOHZNA-M
SMILES C([N+]1([C@@H]2C[C@@H](OC(=O)C(C3C=CC=CC=3)CO)C[C@H]1CC2)C)(C)C.[Br-].O |&1:2,4,18,r|

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