Iodoethane

The Uses of Iodoethane

Iodoethane is an excellent ethylating agent used in organic synthesis to introduce an ethyl group into a compound. It reacts with magnesium to form the Grignard reagent, ethylmagnesium iodide which is used in organic synthesis. It is involved in the preparation of 1-ethyl-3-nitro-2-phenyl-indole and also serves as hydrogen radical promoter.

The Uses of Iodoethane

To a solution of the SM (40 g, 152.1 mmol) in DMF (400 mL) was added K2CO3 (63 g, 456 mmol) and EtI (24.3 mL, 304.2 mmol). The reaction mixture was stirred at RT for 16 h. The mixture was concentrated in vacuo, diluted with H2O (200 mL), and extracted with EtOAc (2 x 200 mL). The combined organics were washed with H2O (100 mL), dried (Na2SO4), and concentrated to provide the product as an off-white solid. [43 g, 95%]

What are the applications of Application

Iodoethane is a useful synthetic reagent for the introduction of ethyl groups