IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER

CAS NO.：39028-27-8
Empirical Formula: C6H6INO4
Molecular Weight: 283.02
MDL number: MFCD00058451
SAFETY DATA SHEET (SDS)
Update Date: 2024-10-23 13:36:13

What is IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER?

Description

SIA Crosslinker is a non-cleavable, water-soluble crosslinker containig an NHS ester and an iodine group. The NHS ester is reactive toward amines while the iodine reacts with thiol groups.

Chemical properties

White Solid

The Uses of IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER

A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Spacer Arm: 1.5 Angstroms

The Uses of IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER

forms water soluble carboxylate derivatives

The Uses of IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER

A sulfhydryl and amino reactive heterobifunctional protein crosslinking reagent. Spacer Arm: 1.5 Angstroms

What are the applications of Application

N-Succinimidyl Iodoacetate is an amine and sulfhydryl reactive crosslinker, 1.5 angstrom spacer arm

Biological Activity

SIA Crosslinker is a non-cleavable ADC linker that can be used to synthesize antibody drug conjugates (ADCs).

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

Properties of IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER

Melting point:	148°C
Boiling point:	315.6±44.0 °C(Predicted)
Density	2.11±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMF: 50 mg/mL
form	powder
color	White to Off-White

Safety information for IODOACETIC ACID N-HYDROXYSUCCINIMIDE ESTER

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.