iobenzamic acid
- CAS NO.:3115-05-7
- Empirical Formula: C16H13I3N2O3
- Molecular Weight: 662
- MDL number: MFCD00867919
- EINECS: 221-484-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-05-09 09:30:45
What is iobenzamic acid?
Originator
Bilibyk,Byk Gulden
The Uses of iobenzamic acid
Diagnostic aid (radiopaque medium, cholecystographic).
Definition
ChEBI: Iobenzamic acid is an organic molecular entity.
Manufacturing Process
1013.2 g 3-amino-2,4,6-triiodobenzoyl chloride are dissolved in a minimum
amount of hot dioxane and caused to flow into 700.6 g molten methyl β-
anilinopropionate with stirring. After the ensuing exothermic reaction has
gradually terminated the reaction mixture is heated on a steam bath for about
3 h and while boiling hot has then methanol and methanolic 3 N HCl added
thereto, where after it is cooled. The precipitated solids are separated and
washed with ether. 953.0 g methyl β-N-(3-amino-2,4,6-triiodobenzoyl)-
phenylaminopropionate are obtained having a melting paint of 156°-157°C.
Yield 74.2% of theory
The methyl ester may be precipitated as the free acid by dissolving in
dioxane, addition of 3.15 N methanolic sodium hydroxide solution, pouring the
resulting reaction mixture in water, and acidulating the solution with 6 N HCl.
After separation and drying, 553.6 g β-N-(3-amino-2,4,6-triiodobenzoyl)-
phenylaminopropionic acid having a melting point of 133°-134.5°C are
obtained from 571.0 g methyl ester. Overall yield 73.46% of theory.
brand name
Osbil (Mallinckrodt).
Therapeutic Function
Diagnostic aid
Safety Profile
Moderately toxic by ingestion andintravenous routes. When heated to decomposition itemits very toxic fumes of I- and NOx.
Properties of iobenzamic acid
Melting point: | 133-134.5° |
Boiling point: | 702.8±60.0 °C(Predicted) |
Density | 2.1751 (estimate) |
pka | 4.15±0.10(Predicted) |
color | White or pale-yellow powder |
Water Solubility | 115mg/L(temperature not stated) |
Safety information for iobenzamic acid
Computed Descriptors for iobenzamic acid
New Products
(R)-3-Aminobutanenitrile Hydrochloride 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine SODIUM AAS SOLUTION ZINC AAS SOLUTION BUFFER SOLUTION PH 10.0(BORATE) GOOCH CRUCIBLE SINTERED AQUANIL 5 BERYLLIUM AAS SOLUTION AMOXICILLIN (AMOXYCILLIN) TRIHYDRATE ACICLOVIR AMLODIPINE SODIUM METHYL PARABEN Methylcobalamin (vitamin B12) SODIUM VALPROATE 5-Fluoro-2-iodo-3-methylaniline Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 1-Methyl-6-oxo-1,6-dihydropyridazine-3-carbonitrile 3-Bromo-2-hydroxybenzeneacetic acid 5-Iodo-3-methyl-2-nitropyridine 1-(3-Chloro-2-hydroxyphenyl)-2-propanoneRelated products of tetrahydrofuran
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