Indobufen
- CAS NO.：63610-08-2
- Empirical Formula: C18H17NO3
- Molecular Weight: 295.34
- MDL number: MFCD00572250
- EINECS: 264-364-4
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-12-18 14:15:30
What is Indobufen?
Description
Indobufen is a platelet aggregation inhibitor related to the antiinflammatory agent indoprofen. It has shown clinical efficacy in peripheral artery disease, in prevention of deep vein thrombosis after myocardial infarction, and in blocking excercise-induced increase in platelet aggregation in angina patients.
Originator
Erbamont (Italy)
The Uses of Indobufen
Indobufen is a platelet aggregation inhibitor. Indobufen is the anticoagulant drug and platelet aggregation inhibitor, which has anti-inflammatory analgesic effect. Indobufen is used as an antithrombotic.
What are the applications of Application
Indobufen is a platelet aggregation inhibitor and reversible cyclooxygenase inhibitor
Definition
ChEBI: Indobufen is a member of isoindoles.
brand name
IBUSTRIN
Clinical Use
A reversible but very potent inhibitor of platelet COX-1 activity, was shown to have comparable clinical efficacy to that of aspirin in prevention of DVT after myocardial infarction and in blocking exercise-induced increase in platelet aggregation. In the secondary prevention of thromboembolic events, 100 or 200 mg of indobufen twice daily is as effective as warfarin or aspirin in patients with or without atrial fibrillation. Currently, indobufen is only available for routine clinical use in Europe.
Properties of Indobufen
| Melting point: | 182-184° |
| Boiling point: | 518.1±50.0 °C(Predicted) |
| Density | 1.275±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 4.39±0.10(Predicted) |
| color | White |
| InChI | InChI=1S/C18H17NO3/c1-2-15(18(21)22)12-7-9-14(10-8-12)19-11-13-5-3-4-6-16(13)17(19)20/h3-10,15H,2,11H2,1H3,(H,21,22) |
| CAS DataBase Reference | 63610-08-2(CAS DataBase Reference) |
| EPA Substance Registry System | Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-.alpha.-ethyl- (63610-08-2) |
Safety information for Indobufen
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral |
| Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for Indobufen
| InChIKey | AYDXAULLCROVIT-UHFFFAOYSA-N |
| SMILES | O=C1C2C=CC=CC=2CN1C1C=CC(C(CC)C(=O)O)=CC=1 |
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