indicine-N-oxide
- CAS NO.：41708-76-3
- Empirical Formula: C15H25NO6
- Molecular Weight: 315.36
- MDL number: MFCD00866484
- SAFETY DATA SHEET (SDS)
- Update Date: 2022-12-21 16:56:50
What is indicine-N-oxide?
Description
Heliotropiurn indicurn also contains this base which has the structure given above based upon comparison with the preceding alkaloid. The base has proved to be highly active against transplanted neoplasts, Walker-256 carcinosarcoma, melanoma B-16, leukaemia L-12l 0, leukaemia P-388 and leukaemia P-1534 in mice and rats, giving up to 91 per cent inhibition of transplanted growth at a daily dosage of 200 mgm. per kilo.
The Uses of indicine-N-oxide
Indicine N-oxide is a pyrrolizidine alkaloid that is isolated from Heliotropium indicum, one of the most widely used herbs in India. Indicine N-oxide exhibits antitumour and antimitotic activity in humans, and has subsequently undergone Phase I & II trials in adults and children with leukemia and solid tumours.
References
Rao, McBride., U.S. Patent, 3,717,710 February 20,1973
Properties of indicine-N-oxide
| Melting point: | 130.5°C (rough estimate) |
| Boiling point: | 454.91°C (rough estimate) |
| Density | 1.1359 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| pka | 12.54±0.29(Predicted) |
Safety information for indicine-N-oxide
Computed Descriptors for indicine-N-oxide
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