IM-12
Synonym(s):3-(4-Fluorophenylethylamino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione
- CAS NO.:1129669-05-1
- Empirical Formula: C22H20FN3O2
- Molecular Weight: 377.41
- MDL number: MFCD20527313
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-06-08 09:02:20
What is IM-12?
Description
Glycogen synthase kinase 3β (GSK3β) is a constitutively active serine/threonine protein kinase implicated in several important regulatory processes. It can phosphorylate β-catenin, an intracellular signal transducer in the Wnt signaling pathway, which leads to β-catenin degradation. IM-12 is a non-symmetrically substituted indolylmaleimide that increases β-catenin levels by inhibiting GSK3β (IC50 = 53 nM). It has been shown to reduce proliferation and increase differentiation of a ReNCell VM cell line derived from human ventral midbrain. IM-12 is also reported to have a depolymerizing effect on in vitro tubulin assembly.
The Uses of IM-12
3-((4-Fluorophenethyl)amino)-1-methyl-4-(2-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione acts as an enhancer of Wnt signalling, involved in cell proliferation or differentiation, via inhibition of glycogen synthase kinase 3 beta (GSK-3β).
Definition
ChEBI: 3-[2-(4-fluorophenyl)ethylamino]-1-methyl-4-(2-methyl-1H-indol-3-yl)pyrrole-2,5-dione is an organonitrogen compound, an organooxygen compound and a member of maleimides. It is functionally related to an alpha-amino acid.
References
[1]. schmöle ac, brennführer a, karapetyan g, et al. novel indolylmaleimide acts as gsk-3beta inhibitor in human neural progenitor cells. bioorg med chem, 2010, 18(18): 6785-6795.
Properties of IM-12
Melting point: | 187 °C |
Boiling point: | 600.2±55.0 °C(Predicted) |
Density | 1.34±0.1 g/cm3(Predicted) |
storage temp. | Sealed in dry,2-8°C |
solubility | DMSO: ≥9mg/mL |
form | powder |
pka | 16.77±0.30(Predicted) |
color | yellow-orange |
Safety information for IM-12
Signal word | Warning |
Pictogram(s) |
Exclamation Mark Irritant GHS07 |
GHS Hazard Statements |
H302:Acute toxicity,oral |
Precautionary Statement Codes |
P280:Wear protective gloves/protective clothing/eye protection/face protection. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for IM-12
New Products
Tubulysin E (R)-tert-butyl (4-methyl-1-oxopentan-3-yl)carbamate Tubulysin C Tubulysin A Potassium HMDS (1.0 M in THF) 4-(Benzyloxy)-3-bromophenylacetic Acid 2,2-Difluoropropylamine hydrochloride 4,4-DIFLUOROCYCLOHEXANAMINE 3-FLUOROPYRROLIDINE HYDROCHLORIDE 4-CYANO-TETRAHYDROPYRAN-4-CARBOXYLIC ACID Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Calcium Sodium Phosphosilicate IH Fuel shell 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate Imeglimin Hydrochloride IH 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 1-(2,3-Dihydro- benzofuran-5-yl) -ethanone 2,3-dichloro-6- nitrobenzonitrile Magnesium Trisilicate Latanoprostene Bunod Lubiprostone Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrileRelated products of tetrahydrofuran
You may like
-
Im-12 95% CAS 1129669-05-1View Details
1129669-05-1 -
IM-12 CAS 1129669-05-1View Details
1129669-05-1 -
Fuel shell 98%View Details
-
4,6-dichloro-2-propylthiopyrimidine-5-amine 145783-15-9 98%View Details
145783-15-9 -
Hydrogen Gas 98%View Details
-
151767-02-1 Montelukast Sodium IP/USP 98%View Details
151767-02-1 -
Valacyclovir Hydrochloride IH 98%View Details
124832-27-5 -
2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol 98%View Details
142569-70-8