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HomeProduct name listIB-MECA

IB-MECA

Synonym(s):1-Deoxy-1-[6-[((3-Iodophenyl)methyl)amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide;N6-(3-Iodobenzyl)adenosine-5′-N-methyluronamide

IB-MECA Structural

What is IB-MECA?

The Uses of IB-MECA

IB-MECA has been used for intraocular pressure and corneal thickness measurements in rabbits.

What are the applications of Application

IB-MECA is a potent and selective Adenosine A3-R agonist

Definition

ChEBI: A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by N-ethylcarboxamido and one of the hydrogens of the exocyclic amino function is substituted by a 3-iodobenzyl group.

Biological Activity

Potent and selective A 3 adenosine receptor agonist (K i values are 1.1, 54 and 56 nM for A 3 , A 1 and A 2A receptors respectively). Cardioprotective, reduces infarct size upon reperfusion in rats.

Biochem/physiol Actions

Selective A3 adenosine receptor agonist.

storage

Desiccate at +4°C

Properties of IB-MECA

Density  1.98±0.1 g/cm3(Predicted)
storage temp.  2-8°C
solubility  hot ethanol: >10 mg/mL
pka 12.72±0.70(Predicted)
form  solid
color  white

Safety information for IB-MECA

Computed Descriptors for IB-MECA

InChIKey HUJXGQILHAUCCV-MOROJQBDSA-N

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