Hyodeoxycholic acid

Synonym(s):3α,6α-Dihydroxy-5β-cholan-24-oic acid

CAS NO.：83-49-8
Empirical Formula: C24H40O4
Molecular Weight: 392.58
MDL number: MFCD00003681
EINECS: 201-483-2
SAFETY DATA SHEET (SDS)
Update Date: 2024-11-29 14:36:51

What is Hyodeoxycholic acid ?

Chemical properties

White Solid

The Uses of Hyodeoxycholic acid

Protected β-Hyodeoxycholic Acid (H998105), a potential bile acid metabolite.

The Uses of Hyodeoxycholic acid

Labelled Hyodeoxycholic Acid. Unlabelled version is isolated from pig bile. Antitumor agent

The Uses of Hyodeoxycholic acid

It is isolated from pig bile. Antitumor agent

The Uses of Hyodeoxycholic acid

Labelled β-Hyodeoxycholic Acid

Definition

ChEBI: A member of the class of 5beta-cholanic acids that is (5beta)-cholan-24-oic acid substituted by alpha-hydroxy groups at positions 3 and 6.

General Description

Hyodeoxycholic acid is a naturally occurring secondary bile acid. It is produced by the gut flora in the small intestine. Hyodeoxycholic acid is obtained from chenodeoxycholic acid during enterohepatic circulation of bile in rats.

Purification Methods

Crystallise -hyodeoxycholic acid from EtOAc or Me2CO. The K salt separates in needles from an alcoholic solution of the acid when an equivalent of KOMe is added (see lithocholic acid). [Weiland & Gumlish Hoppe Seyler's Z Physiol Chem 215 18 1933, Windaus & Bohne Justus Liebigs Ann Chem 433 278 1923, Beilstein 10 III 1631.]

Properties of Hyodeoxycholic acid

Melting point:	200-201 °C (lit.)
Boiling point:	437.26°C (rough estimate)
alpha	D20 +8° (alc)
Density	0.9985 (rough estimate)
refractive index	1.4460 (estimate)
storage temp.	Refrigerator
solubility	Solubility in methanol, very faint turbidity. Slightly soluble in alcohol, acetone, ether and very slightly soluble in chloroform.
form	Solid
pka	4.76±0.10(Predicted)
color	White to Off-White
Water Solubility	5.889mg/L(25 ºC)
Merck	14,4857
CAS DataBase Reference	83-49-8(CAS DataBase Reference)

Safety information for Hyodeoxycholic acid

Signal word	Warning
Pictogram(s)	Exclamation Mark Irritant GHS07
GHS Hazard Statements	H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P304+P340:IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. P405:Store locked up.