CYLINDROSPERMOPSIN
- CAS NO.:143545-90-8
- Empirical Formula: C15H21N5O7S
- Molecular Weight: 415.42
- MDL number: MFCD01939922
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-07-14 17:49:00
What is CYLINDROSPERMOPSIN?
Description
Cylindrospermopsin, a tricyclic uracil derivative, is a cyanobacterial toxin that was first discovered in an algal bloom contaminating a local drinking supply on Palm Island in Queensland, Australia after an outbreak of a mysterious disease. Cylindrospermopsin targets protein and glutathione synthesis in hepatocytes (IC50s = 1.3 and 2.4 μM, respectively), leading to cell death. It has been shown to inhibit the activity of the uridine monophosphate synthase complex with a Ki value of 10 μM. Cylindrospermopsin is genotoxic, inducing DNA damage as evidenced by double strand breaks and reducing cell viability in HepG2 cells at 0.1-
The Uses of CYLINDROSPERMOPSIN
Cylindrospermopsin is a cyanotoxin produced by cyanobacterial species and found in many bodies of water.
What are the applications of Application
Cylindrospermopsin is a cyanotoxin inhibitor of protein synthesis
Definition
ChEBI: A triazaacenaphthylene that is 2,2a,3,4,5,5a,6,7-octahydro-1H-1,8,8b-triazaacenaphthylene which is substituted at positions 3, 4, and 7 by methyl, sulfooxy, and (2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)(hydroxy)methyl groups, respecti ely (the 2aS,3R,4S,5aS,7R stereoisomer in which the carbon bearing the hydroxy group has R configuration). It is a cyanotoxin produced by several species f freshwater cyanobacteria, such as Aphanizomenon ovalisporum.
Properties of CYLINDROSPERMOPSIN
Density | 1.3937 (rough estimate) |
refractive index | 1.6460 (estimate) |
storage temp. | −20°C |
solubility | DMSO: soluble |
form | white powder |
pka | -3.78±0.18(Predicted) |
EPA Substance Registry System | Cylindrospermopsin (143545-90-8) |
Safety information for CYLINDROSPERMOPSIN
Computed Descriptors for CYLINDROSPERMOPSIN
New Products
Tubulysin E Tubulysin H Tubulysin G 1,2,3,6-TETRAHYDROPYRIDINE HYDROCHLORIDE CYCLOBUTYLAMINE HYDROCHLORIDE 2-(azetidin-3-ylidene)acetonitrile (hydrochloride) Methyl (R)-1-Boc-4,4-difluoropyrrolidine-2-carboxylate tetrahydro-4-methyl-2H-pyran 3-Aminocyclobutanone hydrochloride 2-[2-[3(S)-3[2-(7-chloro-2-quinolinyl) ethenyl] phenyl-3- hydroxyl propyl] phenyl]-2-propanol Fuel shell (1R,2S)-2-(3,4-Difluorophenyl)cyclopropanamine Imeglimin Hydrochloride IH Calcium Sodium Phosphosilicate IH 2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]ethanol ethanedioate 4-(2-fluoro-4- nitrophenyl) thiomorpholine (3-Fluoro-4- morpholin-4-yl- phenyl)- carbamic acid methyl ester Lubiprostone Latanoprostene Bunod Magnesium Trisilicate Flame Retardant Zinc Borate 1H-Imidazole-4-carbonitrile 7-Methoxyquinoline-4-carboxylic acid 7-Methoxyquinoline-4-carbonitrileRelated products of tetrahydrofuran
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