Hydroxybupropione

Synonym(s):(±)-Hydroxybupropion solution

CAS NO.：92264-81-8
Empirical Formula: C13H18ClNO2
Molecular Weight: 255.74
MDL number: MFCD03701187
EINECS: 200-835-2
SAFETY DATA SHEET (SDS)
Update Date: 2023-09-04 15:51:00

What is Hydroxybupropione?

Chemical properties

Off-White Solid

The Uses of Hydroxybupropione

A metabolite of Bupropion, an antidepressant. The compound exists mainly as cyclic acetal (2-hydroxy-2-(3?chlorophenyl)-355-trimethylmorpholine). See US Pat. # 6342496

Definition

ChEBI: Hydroxybupropion is an aromatic ketone.

General Description

(±)-Hydroxybupropion is a primary metabolite of bupropion. Bupropion is a pharmaceutical used as an antidepressant and a smoking cessation drug sold under the trade names Wellbutrin^? and Zyban^?. This Certified Spiking Solution^? is suitable for use in LC/MS or GC/MS applications for clinical toxicology, forensic analysis, urine drug testing, or pharmaceutical research.

Properties of Hydroxybupropione

Melting point:	121-123°C
Boiling point:	393.9±32.0 °C(Predicted)
Density	1.150±0.06 g/cm3(Predicted)
Flash point:	2℃
storage temp.	-20°C
solubility	Acetonitrile (Slightly), Chloroform (Slightly), DMSO (Slightly), Methanol (Sligh
form	Solid
pka	15.43±0.10(Predicted)
color	White to Pale Yellow

Safety information for Hydroxybupropione

Signal word	Danger
Pictogram(s)	Flame Flammables GHS02 Exclamation Mark Irritant GHS07
GHS Hazard Statements	H225:Flammable liquids H319:Serious eye damage/eye irritation
Precautionary Statement Codes	P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P337+P313:IF eye irritation persists: Get medical advice/attention. P403+P235:Store in a well-ventilated place. Keep cool.