Hydroxy-PEG3-PFP ester
- CAS NO.：1807537-40-1
- Empirical Formula: C15H17F5O6
- Molecular Weight: 388.28
- MDL number: MFCD26793756
- Update Date: 2024-03-26 13:33:02
What is Hydroxy-PEG3-PFP ester?
Biological Activity
Hydroxy-PEG3-PFP ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of Hydroxy-PEG3-PFP ester
| Boiling point: | 440.3±45.0 °C(Predicted) |
| Density | 1.385±0.06 g/cm3(Predicted) |
| pka | 14.36±0.10(Predicted) |
Safety information for Hydroxy-PEG3-PFP ester
Computed Descriptors for Hydroxy-PEG3-PFP ester
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