PEG6-Tos
- CAS NO.：155130-15-7
- Empirical Formula: C17H28O8S
- Molecular Weight: 392.46
- MDL number: MFCD22574780
- Update Date: 2024-10-28 23:16:16
What is PEG6-Tos?
Description
PEG6-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.
The Uses of PEG6-Tos
Pentaethylene Glycol Monotosylate is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
Properties of PEG6-Tos
| Boiling point: | 524.4±50.0 °C(Predicted) |
| Density | 1.206±0.06 g/cm3(Predicted) |
| solubility | DMSO: 100 mg/mL (254.80 mM) |
| pka | 14.36±0.10(Predicted) |
| form | Liquid |
| color | Colorless to light yellow |
| Water Solubility | Water: 100 mg/mL (254.80 mM) |
Safety information for PEG6-Tos
| Signal word | Warning |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07 |
| GHS Hazard Statements |
H302:Acute toxicity,oral H315:Skin corrosion/irritation H319:Serious eye damage/eye irritation H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P301+P312:IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for PEG6-Tos
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