HYDROQUININE
Synonym(s):(8a,9R)-10,11-Dihydro-6′-methoxycinchonan-9-ol;Dihydroquinine;Hydroquinine;NSC 41799
- CAS NO.：522-66-7
- Empirical Formula: C20H26N2O2
- Molecular Weight: 326.44
- MDL number: MFCD00151107
- EINECS: 208-334-0
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-11-20 11:41:24
What is HYDROQUININE?
Chemical properties
Solid
The Uses of HYDROQUININE
(-)-Dihydroquinine, is a dihydro derivative of Quinine (Q694000), having antipyretic (fever-reducing), antimalarial, analgesic (painkilling), and anti-inflammatory properties.
Definition
ChEBI: Hydroquinine is a cinchona alkaloid.
Purification Methods
Hydroquinine [522-66-7] M 326.4, m 168-171o, 171.5o, [ ] D-143o (c 1.087, EtOH), 5.33 and 8.87. Recrystallise hydroquinine from EtOH, Et2O or *C6H6. [Rabe & Schultz Chem Ber 66 120 1933, Beilstein 23 III/IV 3193, 23/13 V 340.]
Properties of HYDROQUININE
| Melting point: | 168-176 °C(lit.) |
| Boiling point: | 464.47°C (rough estimate) |
| alpha | D18 -142° (alc); D20 -236° (c = 0.82 in 0.1N H2SO4) |
| Density | 1.1117 (rough estimate) |
| refractive index | 1.6800 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | Chloroform (Slightly), Ethanol (Sparingly), Methanol (Slightly) |
| form | Solid |
| pka | 5.33(at 25℃) |
| color | White to Off-White |
| optical activity | [α]25/D 148°, c = 1 in ethanol |
| Water Solubility | 99.99mg/L(20 ºC) |
| Merck | 13,4832 |
| BRN | 91444 |
Safety information for HYDROQUININE
| Signal word | Danger |
| Pictogram(s) |
 Exclamation Mark Irritant GHS07  Health Hazard GHS08 |
| GHS Hazard Statements |
H315:Skin corrosion/irritation H317:Sensitisation, Skin H319:Serious eye damage/eye irritation H334:Sensitisation, respiratory H335:Specific target organ toxicity, single exposure;Respiratory tract irritation |
| Precautionary Statement Codes |
P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P264:Wash hands thoroughly after handling. P264:Wash skin thouroughly after handling. P271:Use only outdoors or in a well-ventilated area. P280:Wear protective gloves/protective clothing/eye protection/face protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing. |
Computed Descriptors for HYDROQUININE
| InChIKey | LJOQGZACKSYWCH-WGFDLZGGSA-N |
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