HYDROETHIDINE
Synonym(s):2,7-Diamino-10-ethyl-9-phenyl-9,10-dihydrophenanthridine;2,7-Diamino-10-ethyl-9-phenyl-9,10-dihydrophenanthridine, DHE;3,8-Diamino-5,6-dihydro-5-ethyl-6-phenylphenanthridine;ActRIIB;Hydroethidine
- CAS NO.:38483-26-0
- Empirical Formula: C21H21N3
- Molecular Weight: 315.41
- MDL number: MFCD00077335
- EINECS: 604-604-1
- SAFETY DATA SHEET (SDS)
- Update Date: 2023-04-23 13:52:06
What is HYDROETHIDINE?
The Uses of HYDROETHIDINE
Dihydroethidium, also known as hydroethidine, is a dye that can permeate viable cells and accumulate in the nucleus after it is dehydrogenated to ethidium bromide and is used to measure oxygen reduction in phagocytes during respiratory burst. In the presence of an oxidant it will fluoresce and has been used as a dye in flow cytometry. Studies have used Dihydroethidium to study alveolar macrophages, blood leukocytes, and epithelial cells, among others, and has be used to measure intracellular H2O2 and O2-, and reactive oxygen. Dyes and metabolites.
General Description
A cell-permeable, chemically reduced ethidium derivative that can be used as a fluorogenic probe for the detection of reactive oxygen species (ROS). It undergoes significant oxidation in resting leukocytes, possibly through the uncoupling of mitochondrial oxidative phosphorylation. Cytosolic dihydroethidium displays blue fluorescence, however, following oxidation to ethidium and subsequent intercalation to DNA, a bright red fluorescence is achieved. Often used to determine the level of superoxide anion in cells by flow cytometry.
Biochem/physiol Actions
Cell permeable: yes
Properties of HYDROETHIDINE
Boiling point: | 444.96°C (rough estimate) |
Density | 1.1227 (rough estimate) |
refractive index | 1.6380 (estimate) |
storage temp. | −20°C |
solubility | acetonitrile: soluble |
CAS DataBase Reference | 38483-26-0(CAS DataBase Reference) |
Safety information for HYDROETHIDINE
Computed Descriptors for HYDROETHIDINE
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
You may like
-
Dihydroethidium CAS 38483-26-0View Details
38483-26-0 -
Anti-Activin Receptor IIB antibody produced in goat CASView Details
-
1823368-42-8 98%View Details
1823368-42-8 -
2-(3-(tert-butyl)phenoxy)-2-methylpropanoic acid 1307449-08-6 98%View Details
1307449-08-6 -
Ethyl 3-(furan-2-yl)-3-hydroxypropanoate 25408-95-1 98%View Details
25408-95-1 -
2-Chloro-5-fluoro-1-methoxy-3-methylbenzene 98%View Details
1805639-70-6 -
1784294-80-9 98%View Details
1784294-80-9 -
Lithium ClavulanateView Details
61177-44-4