HOOCCH2CH2O-PEG10-CH2CH2COOH
- CAS NO.：2097010-30-3
- Empirical Formula: C26H50O15
- Molecular Weight: 602.67
- MDL number: MFCD28385481
- Update Date: 2024-10-28 23:16:16
What is HOOCCH2CH2O-PEG10-CH2CH2COOH?
Biological Activity
Bis-PEG11-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of HOOCCH2CH2O-PEG10-CH2CH2COOH
| Boiling point: | 684.6±55.0 °C(Predicted) |
| Density | 1.165±0.06 g/cm3(Predicted) |
| pka | 3.97±0.10(Predicted) |
Safety information for HOOCCH2CH2O-PEG10-CH2CH2COOH
Computed Descriptors for HOOCCH2CH2O-PEG10-CH2CH2COOH
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