HO-PEG5-CH2COOtBu
- CAS NO.:52026-48-9
- Empirical Formula: C12H24O8
- Molecular Weight: 296.31
- MDL number: MFCD31656910
- Update Date: 2024-10-23 13:36:13
What is HO-PEG5-CH2COOtBu?
Biological Activity
HO-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Properties of HO-PEG5-CH2COOtBu
Boiling point: | 444.5±40.0 °C(Predicted) |
Density | 1.182±0.06 g/cm3(Predicted) |
pka | 3.39±0.10(Predicted) |
Safety information for HO-PEG5-CH2COOtBu
Computed Descriptors for HO-PEG5-CH2COOtBu
New Products
4-AMINO-TETRAHYDRO-PYRAN-4-CARBOXYLIC ACID HCL 4-(Dimethylamino)tetrahydro-2H-pyran-4-carbonitrile 4-Aminotetrahydropyran-4-carbonitrile Hydrochloride (R)-3-Aminobutanenitrile Hydrochloride 3-((Dimethylamino)methyl)-5-methylhexan-2-one oxalate 1,4-Dioxa-8-azaspiro[4.5]decane 5-Bromo-2-nitropyridine Nimesulide BP Aceclofenac IP/BP/EP Diclofenac Sodium IP/BP/EP/USP Mefenamic Acid IP/BP/EP/USP Ornidazole IP Diclofenac Potassium THOMAIND PAPER PH 2.0 TO 4.5 1 BOX BUFFER CAPSULE PH 9.2 - 10 CAP SODIUM CHLORIDE 0.1N CVS ALLOXAN MONOHYDRATE 98% PLATINUM 0.5% ON 3 MM ALUMINA PELLETS (TYPE 73) LITHIUM AAS SOLUTION 2-Bromo-1-(bromomethyl)-3-chloro-5-nitrobenzene 2-Bromo-3-nitroaniline N-(3-Hydroxypropyl)-N-methylacetamide 3-Bromo-6-chloropyridazine 4-ethyl-3-nitrobenzoic acidRelated products of tetrahydrofuran
Hydroxy-PEG5-acid
HOOCCH2CH2O-PEG10-CH2CH2COOH
Acid-PEG4-t-butyl ester
HOOCCH2CH2-PEG16-CH2CH2COOH
COOH-PEG10-COOtBu
HO-PEG3-CH2COOH
HS-PEG4-CH2CH2COOH
HO-PEG6-CH2COOH
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