HOAt
Synonym(s):3H-[1,2,3]-Triazolo[4,5-b]pyridin-3-ol;HOAt
- CAS NO.：39968-33-7
- Empirical Formula: C5H4N4O
- Molecular Weight: 136.11
- MDL number: MFCD00210053
- EINECS: 609-760-3
- SAFETY DATA SHEET (SDS)
- Update Date: 2025-08-19 15:06:19
What is HOAt?
Chemical properties
Clear, colorless liquid
The Uses of HOAt
1-Hydroxy-7-azabenzotriazole can be used as antibacterial, anti-aging and flame-retardant dendritic polyacrylate emulsion. The most used coupling reagents with HOAt are the carbodiimides EDCI, DCC and DIC. HOAt is comparable to HOBt but gives a better performance. It has faster reaction rates, reduced racemisation, higher yields and visual indication of the reaction endpoint by colour change of the reaction mixture from yellow to colourless.
What are the applications of Application
1-Hydroxy-7-azabenzotriazole solution is an activator for peptide synthesis
Description
HOAt is a triazole derivative used in amide coupling chemistry as an additive in combination with coupling agents.
Mechanism
The increased efficiency of HOAt compared to HOBt is related to the stabilisation of the activated intermediate via anchimeric effect, due to the formation of a hydrogen bond with the N atom in position 7 of the benzotriazole.
Properties of HOAt
| Melting point: | 213-216°C |
| Boiling point: | 250.36°C (rough estimate) |
| Density | 0.973 g/mL at 20 °C |
| refractive index | n |
| Flash point: | 213-216°C |
| storage temp. | Store at RT. |
| solubility | >6.8mg/mL in DMSO |
| form | Powder |
| pka | 5.85±0.58(Predicted) |
| Decomposition | 213-216 ºC |
| CAS DataBase Reference | 39968-33-7(CAS DataBase Reference) |
| EPA Substance Registry System | 3H-1,2,3-Triazolo[4,5-b]pyridine, 3-hydroxy- (39968-33-7) |
Safety information for HOAt
Computed Descriptors for HOAt
HOAt manufacturer
JSK Chemicals
ALS India Life Sciences Pvt. Ltd
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