HEXOBARBITAL
- CAS NO.:56-29-1
- Empirical Formula: C12H16N2O3
- Molecular Weight: 236.27
- MDL number: MFCD00057562
- EINECS: 200-264-9
- SAFETY DATA SHEET (SDS)
- Update Date: 2024-03-19 15:37:50
What is HEXOBARBITAL?
Description
Hexobarbital is a barbiturate derivative that has sedative and hypnotic effects. It has been marketed under numerous trade names such as Somnalert, Citopan, and Sombulex. In the 1940s and 1950s, hexobarbital was used as an anesthetic for surgery; but, largely because it is difficult to control the depth of the sedation, it has been replaced by safer drugs, notably the barbiturate thiopental.
Description
Hexobarbital, 5-(cyclohexen-1- yl)-1,5-dimethylbarbituric acid,Mr 236.26. The acid forms colorless crystals that turn pink on exposure to light, mp 146 ?C. A 10 % aqueous solution of the sodium salt, Mr 258.25, has a pH of 11.5.
Chemical properties
White crystals.
The Uses of HEXOBARBITAL
Medicine (sedative).
Definition
ChEBI: A member of the class of barbiturates taht is barbituric acid substituted at N-1 by methyl and at C-5 by methyl and cyclohex-1-enyl groups.
brand name
Cyclonal sodium;Cyclopan;Dorico soluble;Eviderm;Evipal sodium;Evipanl;Hexanal;Hexanastab oral.
World Health Organization (WHO)
Hexobarbital is a short-acting barbiturate. See WHO comment for barbiturates.
Clinical Use
Methohexital sodium is a short-acting anesthetic administered intravenously. It is very potent and has the shortest duration of action among the barbiturates used. A disturbing factor is that rather frequently it causes hiccups directly after injection. Patients are reported to recover rapidly from anesthesia. Abuse can lead to addiction.
Synthesis
Hexobarbital sodium is prepared by condensation of methyl(cyclohexen-1-yl)cyanoacetic ester with dicyanodiamide to 5-(cyclohexen- 1-yl)-5-methyl-2,6-diimino-3-cyanobarbituric acid, followed by methylation with dimethyl sulfate and hydrolysis with 25 % sulfuric acid .
Properties of HEXOBARBITAL
Melting point: | 145-147° |
Boiling point: | 378.73°C (rough estimate) |
Density | 1.1623 (rough estimate) |
refractive index | 1.5460 (estimate) |
Flash point: | 11 °C |
storage temp. | 2-8°C |
pka | 7.99±0.10(Predicted) |
Water Solubility | 434.7mg/L(25 ºC) |
EPA Substance Registry System | Hexobarbital (56-29-1) |
Safety information for HEXOBARBITAL
Signal word | Danger |
Pictogram(s) |
Flame Flammables GHS02 Skull and Crossbones Acute Toxicity GHS06 Health Hazard GHS08 |
GHS Hazard Statements |
H225:Flammable liquids H370:Specific target organ toxicity, single exposure |
Precautionary Statement Codes |
P210:Keep away from heat/sparks/open flames/hot surfaces. — No smoking. P260:Do not breathe dust/fume/gas/mist/vapours/spray. P280:Wear protective gloves/protective clothing/eye protection/face protection. P311:Call a POISON CENTER or doctor/physician. P301+P310:IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
Computed Descriptors for HEXOBARBITAL
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