Hexahydro-4-methylphthalic anhydride

Synonym(s):4-Methyl-1,2-cyclohexanedicarboxylic anhydride

CAS NO.：19438-60-9
Empirical Formula: C9H12O3
Molecular Weight: 168.19
MDL number: MFCD00005927
EINECS: 243-072-0
SAFETY DATA SHEET (SDS)
Update Date: 2023-11-20 10:55:26

Hexahydro-4-methylphthalic anhydride Structural

What is Hexahydro-4-methylphthalic anhydride?

Description

Methylhexahydrophthalic anhydride (MHHP A) is an epoxy hardener, irritant to skin and mucus membranes. It is included in non-diglycidyl-ether-of-bisphenol- A epoxy resins. It can induce both allergic contact dermatitis and immunologic contact urticaria. MHHP A is structurally close to methyltetrahydrophthalic anhydride (MTHP A), which can also cause sensitization.

Chemical properties

Hexahydro-4-methylphthalic anhydride has a melting point of 29 °C, so it is a liquid at room temperature. It has a boiling point of 120 °C and at 25 °C its density is 1.162 g/mL.

The Uses of Hexahydro-4-methylphthalic anhydride

Hexahydro-4-methylphthalic anhydride, mixture of?cis?and?trans may be used as an analytical standard for the determination of the analyte in human biological samples by gas chromatography-mass spectrometry (GC-MS).

General Description

Methylhexahydrophthalic anhydride, a congener of phthalic anhydride, is utilized in the production of plastics, paints, and electronic components. It can potentially result in allergenic effects on humans upon exposure and cause immunological reactions.

Flammability and Explosibility

Non flammable

Contact allergens

Methylhexahydrophthalic anhydride is an epoxy hardener, irritant to skin and mucous membranes. It is included in nondiglycidyl-ether-of-bisphenol-A epoxy resins. It can induce both allergic contact dermatitis and immunologic contact urticaria. It is structurally close to methyltetrahydrophthalic anhydride, which can also cause sensitization.

Synthesis

5-methyl-3a,4,7,7a-tetrahydroisobenzofuran-1,3-dione could used as a starting material to synthesize Hexahydro-4-methylphthalic anhydride. The byproducts include 5-methylisobenzofuran-1,3-dione, 5-methyl-4,5,6,7-tetrahydroisobenzofuran-1,3-dione, and 6-methyl-3a,4,5,7a-tetrahydroisobenzofuran-1,3-dione.

Properties of Hexahydro-4-methylphthalic anhydride

Melting point:	-29°C
Boiling point:	120°C (1 mmHg)
Density	1.162 g/mL at 25 °C(lit.)
vapor pressure	0.23Pa at 25℃
refractive index	n20/D 1.477(lit.)
Flash point:	>230 °F
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly), Ethyl Acetate (Slightly)
pka	4.24[at 20 ℃]
form	Liquid
color	Clear
Water Solubility	REACTS
Sensitive	Moisture Sensitive
Stability:	Hygroscopic, Moisture Sensitive
CAS DataBase Reference	19438-60-9(CAS DataBase Reference)
EPA Substance Registry System	1,3-Isobenzofurandione, hexahydro-5-methyl- (19438-60-9)

Safety information for Hexahydro-4-methylphthalic anhydride

Signal word	Danger
Pictogram(s)	Corrosion Corrosives GHS05 Health Hazard GHS08
GHS Hazard Statements	H317:Sensitisation, Skin H318:Serious eye damage/eye irritation H334:Sensitisation, respiratory
Precautionary Statement Codes	P261:Avoid breathing dust/fume/gas/mist/vapours/spray. P272:Contaminated work clothing should not be allowed out of the workplace. P280:Wear protective gloves/protective clothing/eye protection/face protection. P284:Wear respiratory protection. P302+P352:IF ON SKIN: wash with plenty of soap and water. P305+P351+P338:IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.